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Merck
CN

H2663

Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal

clone HDAC2-62, purified from hybridoma cell culture

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02096544

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产品名称

Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal, clone HDAC2-62, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

HDAC2-62, monoclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

human, chicken, bovine, canine, rat, mouse

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 μg/mL using total cell extracts from NIH3T3 cells

isotype

IgG2b

UniProt accession no.

Q92769

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HDAC2(3066)
mouse ... Hdac2(15182)
rat ... Hdac2(84577)

Application

Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal has been used in:
  • co-immunoprecipitation
  • chromatin immunoprecipitation (ChIP)
  • western blot
  • immunohistochemistry
  • enzyme linked immunosorbent assays (ELISA)

Biochem/physiol Actions

Histone Deacetylases including HDAC′s 1-10 facilitate transcriptional repression and nucleosome condensation. Abnormal recruitment of HDACs by various oncoproteins may occur in certain neoplastic diseases. Inhibition of HDAC2 activity by valproic acid induces proteasomal degradation of HDAC2.
Monoclonal Anti-Histone Deacetylase 2 (HDAC2) recognizes human, bovine, dog, rat, mouse, and chicken HDAC2 (approx. 55 kDa). The antibody epitope resides within amino acids 471-488 of human HDAC2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the HDAC2-62 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the C-terminal region of human histone deacetylase 2 (amino acid residues with N-terminal added cysteine) conjugated to maleimide-activated KLH. Histone deacetylase 2 (HDAC2) is the catalytic subunits of different multiprotein regulatory complexes.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000505857
0000505857
0000466590
0000466590
0000269844

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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Watson PJ, et al.
Nature Communications, 7 (2016)
Dimethyl fumarate regulates histone deacetylase expression in astrocytes
Kalinin S, et al.
Journal of Neuroimmunology, 263 (2013)
Christi Cho et al.
International journal of molecular sciences, 23(3) (2022-02-16)
Epilepsy is a heterogenous neurological disorder characterized by recurrent unprovoked seizures, mitochondrial stress, and neurodegeneration. Hydrogen sulfide (H2S) is a gasotransmitter that promotes mitochondrial function and biogenesis, elicits neuromodulation and neuroprotection, and may acutely suppress seizures. A major gap in
Histone Deacetylases: A Saga of Perturbed Acetylation Homeostasis in Cancer
Parbin S, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62 (2014)
HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells
Kalal BS, et al.
Medical sciences (Basel, Switzerland), 7 (2019)
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