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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
技术
western blot: 1:500
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MT-RNR2(4550)
一般描述
Humanin（HN）是一种小的多肽，来源于线粒体。这种蛋白质由各种细胞分泌，位于血浆中并与细胞膜结合。
免疫原
一种与人蛋白（氨基酸9-24）相对应的肽。
应用
兔生产的抗 Humanin（HN）抗体已被用于：
- 免疫组化
- 免疫沉淀(1:300)
- 免疫荧光(1:300)
- 免疫印迹(1:500)
生化/生理作用
Humanin（HN）是一种神经保护因子。它参与促进细胞存活。Humanin 抑制由阿尔茨海默′病相关损伤引起的神经元细胞死亡，这些相关损伤如抗淀粉样蛋白前体蛋白抗体、神经毒性淀粉样蛋白 β (Aβ) 肽和家族性阿尔茨海默病蛋白。
外形
溶剂为含有0.02％叠氮化钠的1 mg/mL磷酸盐缓冲生理盐水。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Yue Jia et al.
Biology of reproduction, 104(3), 717-730 (2020-12-18)
Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell membrane
Radhika H Muzumdar et al.
PloS one, 4(7), e6334-e6334 (2009-07-23)
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against
Mariela A Moreno Ayala et al.
Scientific reports, 10(1), 8542-8542 (2020-05-24)
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor
Jon-Philippe K Hyatt
Physiological reports, 10(13), e15377-e15377 (2022-07-10)
Skeletal muscle adapts to aerobic exercise training, in part, through fast-to-slow phenotypic shifts and an expansion of mitochondrial networks. Recent research suggests that the local and systemic benefits of exercise training also may be modulated by the mitochondrial-derived peptide, MOTS-c.
Changhan Lee et al.
Trends in endocrinology and metabolism: TEM, 24(5), 222-228 (2013-02-14)
Mitochondria have been largely considered as 'end-function' organelles, servicing the cell by producing energy and regulating cell death in response to complex signals. Being cellular entities with vital roles, mitochondria communicate back to the cell and actively engage in determining
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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