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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
western blot: 1:500
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MT-RNR2(4550)
一般描述
Humanin（HN）是一种小的多肽，来源于线粒体。这种蛋白质由各种细胞分泌，位于血浆中并与细胞膜结合。
免疫原
一种与人蛋白（氨基酸9-24）相对应的肽。
应用
兔生产的抗 Humanin（HN）抗体已被用于：
- 免疫组化
- 免疫沉淀(1:300)
- 免疫荧光(1:300)
- 免疫印迹(1:500)
生化/生理作用
Humanin（HN）是一种神经保护因子。它参与促进细胞存活。Humanin 抑制由阿尔茨海默′病相关损伤引起的神经元细胞死亡，这些相关损伤如抗淀粉样蛋白前体蛋白抗体、神经毒性淀粉样蛋白 β (Aβ) 肽和家族性阿尔茨海默病蛋白。
外形
溶剂为含有0.02％叠氮化钠的1 mg/mL磷酸盐缓冲生理盐水。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Yue Jia et al.
Biology of reproduction, 104(3), 717-730 (2020-12-18)
Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell membrane
Mariela A Moreno Ayala et al.
Scientific reports, 10(1), 8542-8542 (2020-05-24)
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor
Jon-Philippe K Hyatt et al.
Journal of dietary supplements, 20(4), 563-581 (2022-03-02)
Mitochondrial biogenesis and destruction in skeletal muscle are coordinated by distinct signaling pathways that are influenced by internal and exogenous variables including, but not limited to, muscle phenotype, physical activity, dietary composition, or drug administration. Previously we found that long-term
Radhika H Muzumdar et al.
PloS one, 4(7), e6334-e6334 (2009-07-23)
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against
Xingshun Xu et al.
Stroke, 37(10), 2613-2619 (2006-09-09)
Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on focal cerebral ischemia/reperfusion injury
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