H2380
6-羟基-DL-多巴
≥98% (HPLC), powder, APE1 inhibitor
别名:
2,4,5-三羟基-DL-苯丙氨酸, 2,5-二羟基-DL-酪氨酸
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关于此项目
经验公式（希尔记法）:
C9H11NO5
化学文摘社编号:
分子量:
213.19
Beilstein:
2860065
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
产品名称
6-羟基-DL-多巴, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white
溶解性
H2O: 3 mg/mL
1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
储存温度
−20°C
SMILES字符串
NC(Cc1cc(O)c(O)cc1O)C(O)=O
InChI
1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
InChI key
YLKRUSPZOTYMAT-UHFFFAOYSA-N
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一般描述
溶于含有0.1％偏亚硫酸氢钠或其他抗氧化剂的煮沸过的无氧水中。溶液应新鲜制备，并且应避光。
生化/生理作用
6-羟基-DL-DOPA是APE1（紫杉醇/嘧啶内切核酸酶）修复功能活性的一种抑制剂。APE1是一种对DNA碱基切除修复途径至关重要的核酸酶。6-羟基-DL-DOPA还可封闭RAD52（DNA修复蛋白）单链DNA结合结构域。
6-羟基多巴胺前体。
儿茶酚胺能神经毒素6-羟基多巴胺的前体；通过L-芳族氨基酸脱羧酶转化为6-羟基多巴胺。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
免责声明
吸湿；光敏感
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Gurushankar Chandramouly et al.
Chemistry & biology, 22(11), 1491-1504 (2015-11-10)
Suppression of RAD52 causes synthetic lethality in BRCA-deficient cells. Yet pharmacological inhibition of RAD52, which binds single-strand DNA (ssDNA) and lacks enzymatic activity, has not been demonstrated. Here, we identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor
Adnan Azeem et al.
International journal of pharmaceutics, 422(1-2), 436-444 (2011-11-08)
Ropinirole, a recent introduction in the clinical treatment of Parkinson's disease, suffers with the problems of low oral bioavailability and frequent dosing. An effective transdermal nano-emulsion drug delivery system can however resolve these issues effectively with greater therapeutic benefits and
A J Nappi et al.
Biochimica et biophysica acta, 1201(3), 498-504 (1994-12-15)
The interactions of ascorbic acid (AA) and reduced glutathione (GSH) in the oxidations of the catecholaminergic neurotoxins 6-hydroxydopa (TOPA) and 6-hydroxydopamine (6-OHDA) were investigated by both high performance liquid chromatography with electrochemical detection (HPLC-ED) and spectrometric methods. These comparative studies
Annalisa Pinna et al.
Synapse (New York, N.Y.), 61(8), 606-614 (2007-05-04)
Evidence obtained in rodent and primate models of Parkinson's disease (PD) and preliminary clinical trials, indicates that adenosine A(2A) receptor antagonists might represent a promising nondopaminergic therapeutic tool for the treatment of PD. Those studies demonstrated the ability of adenosine
Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase.
G W Adams et al.
Methods in enzymology, 258, 90-114 (1995-01-01)
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