H2380
6-羟基-DL-多巴
≥98% (HPLC), powder, APE1 inhibitor
别名:
2,4,5-三羟基-DL-苯丙氨酸, 2,5-二羟基-DL-酪氨酸
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关于此项目
经验公式（希尔记法）:
C9H11NO5
化学文摘社编号:
分子量:
213.19
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
2860065
产品名称
6-羟基-DL-多巴, ≥98% (HPLC), powder
InChI
1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
SMILES string
NC(Cc1cc(O)c(O)cc1O)C(O)=O
InChI key
YLKRUSPZOTYMAT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
H2O: 3 mg/mL, 1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
storage temp.
−20°C
Quality Level
General description
溶于含有0.1％偏亚硫酸氢钠或其他抗氧化剂的煮沸过的无氧水中。溶液应新鲜制备，并且应避光。
Biochem/physiol Actions
6-羟基-DL-DOPA是APE1（紫杉醇/嘧啶内切核酸酶）修复功能活性的一种抑制剂。APE1是一种对DNA碱基切除修复途径至关重要的核酸酶。6-羟基-DL-DOPA还可封闭RAD52（DNA修复蛋白）单链DNA结合结构域。
6-羟基多巴胺前体。
儿茶酚胺能神经毒素6-羟基多巴胺的前体；通过L-芳族氨基酸脱羧酶转化为6-羟基多巴胺。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
Disclaimer
吸湿；光敏感
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Gurushankar Chandramouly et al.
Chemistry & biology, 22(11), 1491-1504 (2015-11-10)
Suppression of RAD52 causes synthetic lethality in BRCA-deficient cells. Yet pharmacological inhibition of RAD52, which binds single-strand DNA (ssDNA) and lacks enzymatic activity, has not been demonstrated. Here, we identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor
Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase.
G W Adams et al.
Methods in enzymology, 258, 90-114 (1995-01-01)
R M Kostrzewa et al.
Amino acids, 19(1), 183-199 (2000-10-12)
To determine if greater amounts of hydroxyl radical (*OH) are formed by dopamine (DA) denervation and treatment with L-dihydroxyphenylalanine (L-DOPA), the neostriatum was DA denervated (99% reduction in DA content) by 6-hydroxydopamine treatment (134microg icv, desipramine pretreatment) of neonatal rats.
Xiao-Quan Liu et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(8), 523-537 (2020-05-18)
Although several nucleo(s)tide analogs are available for treatment of HBV infection, long-term treatment with these drugs can lead to the emergence of drug-resistant viruses. Recent HIV-1 studies suggest that combination therapies using nucleo(s)tide reverse transcriptase inhibitors (NRTIs) and non-nucleo(s)tide reverse
A Padiglia et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 4(5), 608-613 (1999-11-07)
The reaction with substrates and carbonyl reagents of native lentil Cu-amine oxidase and its modified forms, i.e. Cu-fully-depleted, Cu-half-reconstituted, Cu-fully-reconstituted, Co-substituted, Ni-substituted and Zn-substituted, has been studied. Upon removal of only one of the two Cu ions, the enzyme loses
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