生物来源
human
质量水平
重组
expressed in E. coli
形式
liquid
浓度
1 mg/mL
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... H2BC1(255626)
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一般描述
Histones are highly basic chromatin proteins. They tightly organize eukaryotic DNA into nucleosomes. A nucleosome exists as an octameric core histone comprising a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around the histone complex.
应用
Histone H2B human has been used in far western blot analysis.
生化/生理作用
Histones are known to regulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. Extrachromosomal histone H2B functions as a cytosolic sensor and detects the double-stranded DNA (dsDNA) fragments produced from infectious agents or damaged cells. This stimulates innate and acquired immune responses in different cell types. Histone H2B moves in and out of the nucleosome more quickly than other core histones.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Carc. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Kouji Kobiyama et al.
Frontiers in genetics, 4, 91-91 (2013-06-05)
Histones are essential components of chromatin structure, and histone modification plays an important role in various cellular functions including transcription, gene silencing, and immunity. Histones also play distinct roles in extrachromosomal settings. Extrachromosomal histone H2B acts as a cytosolic sensor
Khoa N Pham et al.
The journal of physical chemistry. B, 125(19), 4977-4986 (2021-05-12)
Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear
Apurva Bhardwaj et al.
International journal of molecular sciences, 22(1) (2021-01-07)
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is an essential protein that regulates cellular processes such as cell proliferation, apoptosis, and differentiation. It is known to bind with several proteins to carry out various cellular functions. In this study, we
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