推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~22 kDa
种属反应性
human, mouse
技术
immunoprecipitation (IP): 5-10 μg using RIPA lysate of human HeLa cells
indirect immunofluorescence: 5-10 μg/mL using mouse NIH3T3 cells
western blot (chemiluminescent): 1-2 μg/mL using whole extract of human HeLa cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CBX5(23468)
mouse ... Cbx5(12419)
免疫原
synthetic peptide corresponding to amino acid residues 177-191 of human HP1a with N-terminal added cysteine, conjugated to KLH. The corresponding sequence in mouse differs by one amino acid.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.
Christèle Maison et al.
Nature communications, 7, 12224-12224 (2016-07-19)
The trimethylation of histone H3 on lysine 9 (H3K9me3) - a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) - has provided a basis for the reader/writer model to explain HP1 accumulation at pericentric heterochromatin in
Shinichi Machida et al.
Molecular cell, 69(3), 385-397 (2018-01-18)
Heterochromatin plays important roles in transcriptional silencing and genome maintenance by the formation of condensed chromatin structures, which determine the epigenetic status of eukaryotic cells. The trimethylation of histone H3 lysine 9 (H3K9me3), a target of heterochromatin protein 1 (HP1), is
Alba Millanes-Romero et al.
Molecular cell, 52(5), 746-757 (2013-11-19)
Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of heterochromatin, little is known about how their transcription is
Julio Aguado et al.
Nature communications, 10(1), 4990-4990 (2019-11-20)
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction
Joseph Dopie et al.
The Journal of cell biology, 219(9) (2020-07-02)
We present a simple ratio method to infer protein composition within cellular structures using proximity labeling approaches but compensating for the diffusion of free radicals. We used tyramide signal amplification (TSA) and label-free mass spectrometry (MS) to compare proteins in
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