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生物来源
human
质量水平
重组
expressed in E. coli
形式
liquid
浓度
1 mg/mL
UniProt登记号
应用
cell analysis
运输
wet ice
储存温度
−20°C
基因信息
human ... H2AC20(8338)
一般描述
Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.
应用
Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.
生化/生理作用
Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.
外形
Supplied in 20 mM Na3PO4, pH 7.0, 0.3 M NaCl and 1 mM EDTA
警示用语：
Danger
危险声明
预防措施声明
危险分类
Carc. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Khoa N Pham et al.
The journal of physical chemistry. B, 125(19), 4977-4986 (2021-05-12)
Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear
Apurva Bhardwaj et al.
International journal of molecular sciences, 22(1) (2021-01-07)
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is an essential protein that regulates cellular processes such as cell proliferation, apoptosis, and differentiation. It is known to bind with several proteins to carry out various cellular functions. In this study, we
Luis Donis-Maturano et al.
SpringerPlus, 4, 161-161 (2015-04-18)
Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules contributing to inflammation. Recently, a novel antimicrobial mechanism was discovered; the Neutrophil Extracelullar Traps (NETs) formed
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