推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~30 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells over expressing human HOXC9
indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells, over expressing human HOXC9
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over expressing human HOXC9
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HOXC8(3224)
mouse ... Hoxc8(15426)
rat ... Hoxc9(368178)
一般描述
Homeobox C9 (HOXC9) gene is a member of the conserved homeobox family and is located on the human chromosome at 12q13.13. This gene encodes for the HOXC9 transcription factor/protein.
特异性
Anti-HOXC9 (C-terminal) recognizes human HOXC9 (also known as Hox-3B).
应用
Anti-HOXC9 (C-terminal) antibody produced in rabbit may be used in
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
Homeobox C9 (HOXC9) transcription factor/ protein is involved in morphogenesis. Loss of this gene is associated with a hypermethylated state of its promoter in non-small cell lung cancer and breast cancer. HOXC9 protein produces neuronal differentiation and growth arrest in neuroblastoma cells and acts as a biomarker in neuroblastoma patients. HOXC9 gene expression is upregulated by retinoic acid. The HOXC9 gene expression is associated with astrocytomas malignancy and cervical cancer.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
新产品
R López et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16(3), 1289-1296 (2006-06-29)
The HOX genes are a family of transcription factors that bind to specific sequences of DNA in target genes regulating their expression. The role of HOX genes in adult cell differentiation is still obscure, but growing evidence suggests that they
Xudong Peng et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(4), 1659-1676 (2018-09-12)
Previous studies demonstrated that HOXC9 acts as an oncogene in several tumors. The aim of this study was to explore whether HOXC9 promotes gastric cancer (GC) progression and elucidate the underlying molecular mechanisms. HOXC9 expression in GC tissues and adjacent
Oswaldo K Okamoto et al.
Biochimica et biophysica acta, 1769(7-8), 437-442 (2007-06-26)
Comparative analysis of cancer stem cells with their neoplastic and non-neoplastic counterparts should help better understand the underlying molecular events leading to transformation and tumor dissemination. Here, we report a molecular signature comprised by genes with exclusive aberrant expression in
Ling Mao et al.
Cancer research, 71(12), 4314-4324 (2011-04-22)
Differentiation status in neuroblastoma strongly affects clinical outcomes and inducing differentiation is a treatment strategy in this disease. However, the molecular mechanisms that control neuroblastoma differentiation are not well understood. Here, we show that high-level HOXC9 expression is associated with
Lei Lv et al.
Cancer letters, 357(1), 105-113 (2014-12-03)
Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2.
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