H1916
Anti-HOXC9 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-HOX3B, Anti-Homeobox 3B, Anti-Homeobox C9, Anti-Hox-3.2 (MOUSE)
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~30 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells over expressing human HOXC9, indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells, over expressing human HOXC9, western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over expressing human HOXC9
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXC8(3224)
mouse ... Hoxc8(15426)
rat ... Hoxc9(368178)
General description
Homeobox C9 (HOXC9) gene is a member of the conserved homeobox family and is located on the human chromosome at 12q13.13. This gene encodes for the HOXC9 transcription factor/protein.
Application
Anti-HOXC9 (C-terminal) antibody produced in rabbit may be used in
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Anti-HOXC9 (C-terminal) recognizes human HOXC9 (also known as Hox-3B).
Homeobox C9 (HOXC9) transcription factor/ protein is involved in morphogenesis. Loss of this gene is associated with a hypermethylated state of its promoter in non-small cell lung cancer and breast cancer. HOXC9 protein produces neuronal differentiation and growth arrest in neuroblastoma cells and acts as a biomarker in neuroblastoma patients. HOXC9 gene expression is upregulated by retinoic acid. The HOXC9 gene expression is associated with astrocytomas malignancy and cervical cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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R López et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16(3), 1289-1296 (2006-06-29)
The HOX genes are a family of transcription factors that bind to specific sequences of DNA in target genes regulating their expression. The role of HOX genes in adult cell differentiation is still obscure, but growing evidence suggests that they
Xudong Peng et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(4), 1659-1676 (2018-09-12)
Previous studies demonstrated that HOXC9 acts as an oncogene in several tumors. The aim of this study was to explore whether HOXC9 promotes gastric cancer (GC) progression and elucidate the underlying molecular mechanisms. HOXC9 expression in GC tissues and adjacent
Oswaldo K Okamoto et al.
Biochimica et biophysica acta, 1769(7-8), 437-442 (2007-06-26)
Comparative analysis of cancer stem cells with their neoplastic and non-neoplastic counterparts should help better understand the underlying molecular events leading to transformation and tumor dissemination. Here, we report a molecular signature comprised by genes with exclusive aberrant expression in
Ling Mao et al.
Cancer research, 71(12), 4314-4324 (2011-04-22)
Differentiation status in neuroblastoma strongly affects clinical outcomes and inducing differentiation is a treatment strategy in this disease. However, the molecular mechanisms that control neuroblastoma differentiation are not well understood. Here, we show that high-level HOXC9 expression is associated with
Lei Lv et al.
Cancer letters, 357(1), 105-113 (2014-12-03)
Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2.
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