H1775
Monoclonal Anti-Heat Shock Protein 90 antibody produced in mouse
clone AC-16, ascites fluid
别名:
Anti-EL52, Anti-HEL-S-65p, Anti-HSP86, Anti-HSP89A, Anti-HSP90A, Anti-HSP90N, Anti-HSPC1, Anti-HSPCA, Anti-HSPCAL1, Anti-HSPCAL4, Anti-HSPN, Anti-Hsp103, Anti-Hsp89, Anti-Hsp90, Anti-LAP-2, Anti-LAP2
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About This Item
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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
AC-16, monoclonal
分子量
antigen 88 kDa
包含
15 mM sodium azide
种属反应性
wheat germ, chicken, Sf9 cell line, rabbit, rat, human, mouse, Achlya
包装
antibody small pack of 25 μL
一般描述
HSP90AB1 (heat shock protein 90α family class B member 1) belongs to the Hsp90 family. It consists of major members-Hsp90α, Hsp90β, GRP94 (glucose-regulated protein 94) and Hsp75. It is located on chromosome 6p21. HSP90AB1is an ATP-dependent molecular chaperone, having a molecular weight of 90kDa. HSP90AA1 is located on human chromosome 14q32.31.
特异性
The antibody is reactive with both the constitutive and the inducible forms of HSP90. However, it does not bind to the native form of HSP90. It does not recognize HSP90 from E. coli and yeast.
免疫原
heat shock protein 90 (HSP90) from the water mold Achlya ambisexualis
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Heat Shock Protein 90 antibody has been used in ovarian histomorphology, immunohistochemistry and western blotting.
生化/生理作用
HSP90AB1 (heat shock protein 90α family class B member 1) participates in signal transduction, protein folding and degradation, and morphological evolution. It is required for the transport of client proteins between the cytoplasm and nucleus. In lung adenocarcinoma patients, overexpression of HSP90AB1 in non-small cell lung cancer tissues results in imperfect clinical predictions. Suppression of this gene reduces the potential of endothelial cells to form tube structures.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
X-S Liu et al.
Oncogene, 35(23), 3071-3078 (2015-10-13)
We recently reported that ZBTB7A is a bona fide transcription repressor of key glycolytic genes and its downregulation in human cancer contributes to tumor metabolism. As reduced expression of ZBTB7A is found only in a subset of human cancers, we
Antioxidant and molecular chaperone defences during estivation and arousal in the South American apple snail Pomacea canaliculata
Giraud B M, et al.
The Journal of Experimental Biology, 216(4), 614-622 (2013)
t (3; 14)(q27; q32) HSP90AA1/BCL6
Huret J L.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2013)
Hsp90AB1 Protein is Overexpressed in Non-small Cell Lung Cancer Tissues and Associated with Poor Prognosis in Lung Adenocarcinoma Patients
Wang M, et al.
Chinese Journal of Analytical Chemistry, 19(2), 64-69 (2016)
Exposure to chemical cocktails before or after conception-the effect of timing on ovarian development
Bellingham M, et al.
Molecular and Cellular Endocrinology, 376(1-2), 156-172 (2013)
商品
Quantitative and qualitative western blotting to validate knockdown by esiRNA.
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