所有图片(3)
About This Item
经验公式（希尔记法）:
C10H12N2O4
CAS号:
分子量:
224.21
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
一般描述
3-羟基-DL-犬尿氨酸是一种色氨酸代谢产物，分子量相应的 224 Da。是存在于眼睛晶状体中的发色团或亲水性黄色化合物。3-羟基-DL-犬尿氨酸是由犬尿氨酸在犬尿氨酸 3-单加氧酶 (KMO) 操作下合成的。在犬尿氨酸酶和犬尿氨酸氨基转移酶的作用下，分别代谢为 3-羟基邻氨基苯甲酸和黄尿酸。
应用
3-羟基-DL-犬尿氨酸已被用于：
- 作为重组人犬尿氨酸酶检测的底物
- 作为串联质谱 (MS/MS) 分析的引用标准品
- 作为定量糖尿病视网膜病变患者血清 3-羟基-DL-犬尿氨酸水平的对照品
生化/生理作用
3-羟基-DL-犬尿氨酸 (3-HKYN) 具有抗氧化功能，可防止大脑皮层脂质过氧化。可能调节突触神经传递。Huntington 病患者血浆中 3-HKYN 水平升高。然而，它在神经退行性疾病中的作用仍不十分清楚。犬尿氨酸代谢与谷氨酸能神经传递相关，3-HKYN 水平与精神分裂症的病理生理学相关。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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