H1753
肼屈嗪 盐酸盐
synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder
别名:
1-肼基二氮杂萘 盐酸盐
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关于此项目
经验公式（希尔记法）:
C8H8N4 · HCl
化学文摘社编号:
分子量:
196.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-151-0
MDL number:
Assay:
≥99% (TLC)
Form:
powder
产品名称
肼屈嗪 盐酸盐,
biological source
synthetic (organic)
assay
≥99% (TLC)
form
powder
mp
273 °C
solubility
water: 50 mg/mL
SMILES string
Cl[H].N\N=C1/N=NC=C2C=CC=CC12
InChI
1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;
InChI key
SECXUXOCDLQOBI-MKFZHGHUSA-N
Gene Information
human ... MAOA(4128), MAOB(4129)
Application
盐酸肼屈嗪已用于：
- 研究其作为血管扩张药，对大鼠幼鼠T细胞频率升高相关高血压的影响
- 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂，对心肌缺血再灌注(I/R)损伤的影响
- 研究其作为血管扩张药，对胰岛素分泌和葡萄糖耐受的影响
Biochem/physiol Actions
盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。
抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。
Features and Benefits
该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
商品
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
Nadine S Sauter et al.
Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
Ruijia Feng et al.
Gut microbes, 16(1), 2390164-2390164 (2024-08-18)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model
Waste tea residue as a low cost adsorbent for removal of hydralazine hydrochloride pharmaceutical pollutant from aqueous media: An environmental remediation
Patil C S, et al.
Journal of Cleaner Production, 206, 407-418 (2019)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H1753-50G | 04061832947860 |
| H1753-5G | 04061833697726 |
| H1753-10G | 04061833697719 |