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描述
neurotrophic to dopaminergic neurons
质量水平
检测方案
≥98% (HPLC)
形式
powder
药品控制
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
SMILES字符串
Br.Oc1ccc2C[C@@H]3NCC[C@]4(CCCC[C@H]34)c2c1
InChI
1S/C16H21NO.BrH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m1./s1
InChI key
LJAQABDSIONCIU-KHUAAREISA-N
Tzu-Yu Lin et al.
Neurochemistry international, 54(8), 526-534 (2009-05-12)
Dextromethorphan (DM), a widely used antitussive, has demonstrated an effective neuroprotective effect. Excessive release of glutamate is considered to be an underlying cause of neuronal damage in several neurological diseases. In the present study, we investigated whether DM or its
Eun-Joo Shin et al.
Journal of pharmacological sciences, 106(1), 22-27 (2008-01-17)
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to
S J Vetticaden et al.
Pharmaceutical research, 6(1), 13-19 (1989-01-01)
Polymorphic differences in dextromethorphan metabolism were observed in three studies conducted in a total of 44 subjects (of Dutch origin) administered 60 mg dextromethorphan hydrobromide as an OROS tablet. Mean plasma dextromethorphan (DM) concentrations after a single dose and at
Timothy S Tracy et al.
American journal of obstetrics and gynecology, 192(2), 633-639 (2005-02-08)
The purpose of this study was to determine whether drug metabolism (CYP1A2, CYP2D6 and CYP3A) activity varies in the pregnant state compared with the nonpregnant state. Subjects were studied at 14 to18 weeks of gestation, 24 to 28 weeks of
Z R Chen et al.
Therapeutic drug monitoring, 12(1), 97-104 (1990-01-01)
A simple, sensitive, and reproducible high-performance liquid chromatrography assay is described for the simultaneous determination of dextromethophan, dextrorphan, 3-hydroxymorphinan, and 3-methoxymorphinan in plasma and urine. A conventional solvent-solvent extraction procedure was used for the isolation of the analytes from plasma
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