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描述
neurotrophic to dopaminergic neurons
质量水平
方案
≥98% (HPLC)
表单
powder
药品控制
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
SMILES字符串
Br.Oc1ccc2C[C@@H]3NCC[C@]4(CCCC[C@H]34)c2c1
InChI
1S/C16H21NO.BrH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m1./s1
InChI key
LJAQABDSIONCIU-KHUAAREISA-N
S J Vetticaden et al.
Pharmaceutical research, 6(1), 13-19 (1989-01-01)
Polymorphic differences in dextromethorphan metabolism were observed in three studies conducted in a total of 44 subjects (of Dutch origin) administered 60 mg dextromethorphan hydrobromide as an OROS tablet. Mean plasma dextromethorphan (DM) concentrations after a single dose and at
Eun-Joo Shin et al.
Journal of pharmacological sciences, 106(1), 22-27 (2008-01-17)
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to
Tzu-Yu Lin et al.
Neurochemistry international, 54(8), 526-534 (2009-05-12)
Dextromethorphan (DM), a widely used antitussive, has demonstrated an effective neuroprotective effect. Excessive release of glutamate is considered to be an underlying cause of neuronal damage in several neurological diseases. In the present study, we investigated whether DM or its
Timothy S Tracy et al.
American journal of obstetrics and gynecology, 192(2), 633-639 (2005-02-08)
The purpose of this study was to determine whether drug metabolism (CYP1A2, CYP2D6 and CYP3A) activity varies in the pregnant state compared with the nonpregnant state. Subjects were studied at 14 to18 weeks of gestation, 24 to 28 weeks of
Wei Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20(14), 2496-2511 (2006-12-05)
We investigated the neuroprotective property of analogs of dextromethorphan (DM) in lipopolysaccharide (LPS) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models to identify neuroprotective drugs for Parkinson's disease (PD). In vivo studies showed that daily injections with DM analogs protected dopamine (DA) neurons in
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