生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~40 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 5-10 μg/mL using lysates of HEK-293T cells over expressing human HOXC4
indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXC4
western blot: 5-10 μg/mL using lysates of HEK-293T cells over expressing human HOXC4
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HOXC4(3221)
mouse ... Hoxc4(15423)
rat ... Hoxc4(24459)
一般描述
The homeobox C4 (HOXC4) gene is mapped on the human chromosome at 12q13.13.
特异性
Anti-HOXC4 (C-terminal) recognizes human HOXC4 (also known as Hox-3E and CP19).
应用
Anti-HOXC4 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
Homeobox C4 (HOXC4) transcription factor/protein is involved in inducing the function of activation-induced cytosine deaminase (AID). Upregulation of the HOXC4 gene is due to the estrogen-estrogen receptor complexes. HOXC4 gene is expressed in the nucleus of activated human lymphocytes and the increased expression level is observed with the progression of lymphoid differentiation.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
常规特殊物品
R Meazza et al.
Blood, 85(8), 2084-2090 (1995-04-15)
We have analyzed the expression of homeoproteins of the HOX family in resting and activated lymphoid cells and in neoplastic lymphoid cell lines by the use of monoclonal antibodies (MoAbs) already shown to react with the homeoproteins HOXA10, HOXC6, and
J van Oostveen et al.
Leukemia, 13(11), 1675-1690 (1999-11-11)
In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in addition, they are contributing to organization and regulation of hematopoiesis. Modern molecular technologies showed
Seok-Rae Park et al.
Cytokine, 61(2), 608-613 (2012-11-28)
Activation-induced cytidine deaminase (AID) plays a key role in B cell immunoglobulin (Ig) class switch recombination (CSR) and somatic hypermutation (SHM). We have previously reported that the highly conserved homeodomain HoxC4 transcription factor binds to the Aicda (AID gene) promoter
Frank Mendrzyk et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(7 Pt 1), 2070-2079 (2006-04-13)
Pathogenesis of ependymomas is still poorly understood and molecular markers for risk-adapted patient stratification are not available. Our aim was to screen for novel genomic imbalances and prognostic markers in ependymal tumors. We analyzed 68 sporadic tumors by matrix-based comparative
Thach Mai et al.
The Journal of biological chemistry, 285(48), 37797-37810 (2010-09-22)
Estrogen enhances antibody and autoantibody responses through yet to be defined mechanisms. It has been suggested that estrogen up-regulates the expression of activation-induced cytosine deaminase (AID), which is critical for antibody class switch DNA recombination (CSR) and somatic hypermutation (SHM)
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