H1506
3α-羟甾类脱氢酶 来源于睾丸酮假单胞菌
≥15 units/mg protein
别名:
3α-羟甾类:NAD(P)+氧化还原酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-839-5
MDL number:
Specific activity:
≥15 units/mg protein
Biological source:
bacterial (Pseudomonas testosteroni)
biological source
bacterial (Pseudomonas testosteroni)
form
lyophilized solid
specific activity
≥15 units/mg protein
purified by
chromatography
composition
Protein, ≥25%
foreign activity
β-hydroxysteroid dehydrogenase ≤0.5%, alcohol dehydrogenase ≤0.05%
storage temp.
−20°C
Quality Level
Application
来源于假单胞菌 睾丸激素的3α-羟基类固醇脱氢酶已被用于：
- 制备复合电极平台，以用于测定雄甾酮
- 磷酸钾缓冲液中，以用于血清中胆汁酸的生物发光测定
- 通过酶法测定总胆汁盐
Biochem/physiol Actions
3α-羟基类固醇脱氢酶 (3α-HSD) 可以帮助调节雄激素靶组织中雄激素受体 (AR) 的占据。它也可阻碍雄激素的作用。
Physical form
含有磷酸钾缓冲盐、EDTA和DL-二硫苏糖醇的冻干粉末
Other Notes
在β-NAD+存在，pH8.9，25℃条件下，一个单位每分钟可氧化1.0 μmole雄甾酮。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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The Journal of clinical endocrinology and metabolism, 93(4), 1298-1303 (2008-02-07)
Dihydrotestosterone (DHT), the primary active androgen in peripheral target tissues, is metabolized by 3alpha-hydroxysteroid dehydrogenase type III (3alpha-HSD), encoded by the AKR1C2 gene, forming 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). 3alpha-HSD may play a role in the pathogenesis of hirsutism. Our objective was to
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Identification of cellular targets pertinent for the development of effective therapies against pathological pain constitutes a difficult challenge. We combined several approaches to show that 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR), abundantly expressed in the spinal cord (SC), is a key target, the
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