推荐产品
应用
来源于假单胞菌 睾丸激素的3α-羟基类固醇脱氢酶已被用于：
- 制备复合电极平台，以用于测定雄甾酮
- 磷酸钾缓冲液中，以用于血清中胆汁酸的生物发光测定
- 通过酶法测定总胆汁盐
生化/生理作用
3α-羟基类固醇脱氢酶 (3α-HSD) 可以帮助调节雄激素靶组织中雄激素受体 (AR) 的占据。它也可阻碍雄激素的作用。
单位定义
在β-NAD+存在，pH8.9，25℃条件下，一个单位每分钟可氧化1.0 μmole雄甾酮。
外形
含有磷酸钾缓冲盐、EDTA和DL-二硫苏糖醇的冻干粉末
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Bioluminescent assay for total bile acids in serum with use of bacterial luciferase.
Styrelius I, et al.
Clinical Chemistry, 29(6), 1123-1127 (1983)
Anne Z Steiner et al.
The Journal of clinical endocrinology and metabolism, 93(4), 1298-1303 (2008-02-07)
Dihydrotestosterone (DHT), the primary active androgen in peripheral target tissues, is metabolized by 3alpha-hydroxysteroid dehydrogenase type III (3alpha-HSD), encoded by the AKR1C2 gene, forming 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). 3alpha-HSD may play a role in the pathogenesis of hirsutism. Our objective was to
Phytosterol ester processing in the small intestine; impact on cholesterol availability for absorption and chylomicron cholesterol incorporation in healthy humans
Amiot MJ, et al.
Journal of Lipid Research, jlr-M013730 (2011)
Enzyme biosensor for androsterone based on 3alpha-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode
Mundaca RA, et al.
Talanta, 99(, 697-702 (2012)
Laurence Meyer et al.
Neurobiology of disease, 30(1), 30-41 (2008-02-23)
Identification of cellular targets pertinent for the development of effective therapies against pathological pain constitutes a difficult challenge. We combined several approaches to show that 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR), abundantly expressed in the spinal cord (SC), is a key target, the
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