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Merck
CN

H139

Sigma-Aldrich

HA-1077 二盐酸盐

solid, ≥98% (HPLC)

别名:

1-(5-异喹啉磺酰基)高哌嗪 二盐酸盐, 法舒地尔 二盐酸盐

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About This Item

经验公式(希尔记法):
C14H17N3O2S · 2HCl
分子量:
364.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

solid

储存条件

desiccated

颜色

white to off-white

溶解性

H2O: >10 mg/mL

SMILES字符串

Cl[H].Cl[H].O=S(=O)(N1CCCNCC1)c2cccc3cnccc23

InChI

1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H

InChI key

NOXXIYDYFSNHDF-UHFFFAOYSA-N

应用

HA-1077 二盐酸盐已被用于:
  • 舒张悬臂梁
  • 在离体冠状动脉功能评估中的作用
  • ,以探讨氮杂吲哚-1、法舒地尔对急性缺氧性肺血管收缩 (HPV)

生化/生理作用

HA-1077/法舒地尔 是一种 Rho 激酶抑制剂。这种 ROCK 抑制剂能够增加患有阿尔茨海默氏症(AD)的动物的认知缺陷。在人体中,法舒地尔对蛛网膜下腔出血 (SAH) 后脑血管痉挛具有较好的治疗作用。HA-1077 也可作为蛋白激酶的抑制剂,如肌球蛋白轻链激酶和 Rho 相关激酶。因此,它可以阻止肌球蛋白磷酸化。
作为细胞内 Ca2+ 拮抗剂抑制血管平滑肌收缩的新型血管扩张剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Manar Hamed Arafa et al.
Life sciences, 254, 117605-117605 (2020-04-13)
Although chloroquine and diclofenac are not cardiovascular drugs, their chronic administration may trigger cardiotoxicity. We, therefore, evaluated the cardiotoxic impact of diclofenac in chloroquine-treated adjuvant arthritic rats and the protective role of Rho-kinase inhibitors. 90 male rats were equally distributed
Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho-kinase-dependent pathway
Noblet J N, et al.
Basic Research in Cardiology, 111(3), 25-25 (2016)
Fasudil exerts cardioprotection in Animal Models of Myocardial Ischemia/Reperfusion injury: A Meta-analysis and Review of Preclinical Evidence and Possible Mechanisms
Huang Y, et al.
Frontiers in Pharmacology, 9, 1083-1083 (2018)
M Seto et al.
European journal of pharmacology, 195(2), 267-272 (1991-03-26)
We examined the effects of HA1077, a potent inhibitor of protein kinases in vitro, on the relationship between tension and myosin-light chain (MLC20) phosphorylation in the initial phase of contraction of the rabbit aorta. The dose-response curve of HA1077 for
Protective effects of the ROCK inhibitor fasudil against cognitive dysfunction following status epilepticus in male rats
Song X, et al.
Journal of Neuroscience Research (2018)

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