质量水平
检测方案
≥95% (HPLC)
形式
solid
颜色
white
溶解性
ethanol: 1.3 mg/mL
H2O: 10 mg/mL
SMILES字符串
[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4
InChI
1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2
InChI key
OPYKHUMNFAMIBL-UHFFFAOYSA-L
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应用
半胆碱基-3已被用于制备Krebs-HC-3缓冲液，研究其对分化的人神经母细胞瘤（SK-N-SH）细胞中胆碱摄取和胆碱乙酰转移酶活性的影响。
生化/生理作用
半胆碱基-3在阻止神经元胆碱摄取方面起一定的作用，从而可以抑制大脑中乙酰胆碱的合成。
特点和优势
该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Effect of hemicholinium-3 on the hypothalamic concentration of a cytochemically detectable glucose-6-phosphate dehydrogenase-stimulating substance.
Vargas, H M, et al.
Journal of Cardiovascular Pharmacology, 24(5), 773-778 (1994)
Theodore A Slotkin et al.
Environmental health perspectives, 117(6), 916-922 (2009-07-11)
Developmental exposure to a wide variety of developmental neurotoxicants, including organophosphate pesticides, evokes late-emerging and persistent abnormalities in acetylcholine (ACh) systems. We are seeking interventions that can ameliorate or reverse the effects later in life. We administered parathion to neonatal
Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells
Ray B, et al.
Brain Research, 1297(5), 160-168 (2009)
Yu Kuang et al.
Molecular pharmaceutics, 7(6), 2077-2092 (2010-08-12)
Altered choline (Cho) metabolism in cancerous cells can be used as a basis for molecular imaging with PET using radiolabeled Cho. In this study, the metabolism of tracer Cho was investigated in a woodchuck hepatocellular carcinoma (HCC) cell line (WCH17)
Structure-activity aspects of hemicholinium-3 (HC-3) and its analogs and congeners.
J G Cannon
Medicinal research reviews, 14(5), 505-531 (1994-09-01)
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