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Merck
CN

H0916

Sigma-Aldrich

Anti-HOXA10 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-HOMEOBOX 1H, Anti-HOMEOBOX A10, Anti-HOX-1.8, Anti-HOX1H

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~50 kDa

种属反应性

human

浓度

~1.0 mg/mL

技术

western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human HOXA10

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... HOXA10(3206)

一般描述

The homeobox A10 (HOXA10) protein is localized in the adult human endometrium. The HOXA10 gene is mapped on the human chromosome at 7p15.2.

特异性

Anti-HOXA10 (N-terminal) recognizes human HOXA10 (also known as Hox-1H and HOX-1).

应用

Anti-HOXA10 (N-terminal) antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Homeobox A10 (HOXA10) protein is critical for the normal development of the erythroid and megakaryocytic lineages. The expression of the HOXA10 gene was found to be altered in endometriosis. HOXA10 protein plays a role in mediating endometrial development during the menstrual cycle. This protein is also involved in preparing the endometrium for implantation in humans.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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访问文档库

J Julie Kim et al.
Molecular human reproduction, 13(5), 323-332 (2007-03-14)
Endometriosis is a poorly understood gynaecologic disorder that is associated with infertility. In this study, we examined the expression of HOXA10 in the eutopic endometrium of baboons with induced endometriosis. A decrease in HOXA10 mRNA was observed after 3, 6
H S Taylor et al.
The Journal of clinical investigation, 101(7), 1379-1384 (1998-04-29)
Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit uterine factor infertility. We have recently demonstrated that HOXA10 is expressed in
Alysson Zanatta et al.
Journal of assisted reproduction and genetics, 27(12), 701-710 (2010-09-08)
endometriosis and its associated infertility have been the object of continuous research for over a century. To understand the molecular mechanisms underlying the disease, it has become necessary to determine the aspects of its etiology that are not explained by
Edward J Richards et al.
Oncotarget, 6(33), 34745-34757 (2015-10-03)
The homeobox A (HOXA) region of protein-coding genes impacts female reproductive system embryogenesis and ovarian carcinogenesis. The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplored in epithelial ovarian cancer (EOC). We
Nan Zhu et al.
The Journal of clinical investigation, 126(3), 997-1011 (2016-02-16)
Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are required for LSC, but not HSC, function could provide therapeutic opportunities that are more effective and less toxic

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