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Merck
CN

H0878

Sigma-Aldrich

肝素 锂盐 来源于猪肠粘膜

≥150 USP units/mg

别名:

Lithium acid heparin, Lithium heparinate

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352201
NACRES:
NA.25

生物来源

Porcine intestinal mucosa

质量水平

表单

powder

比活

≥150 USP units/mg

颜色

off-white

溶解性

water: 40 mg/mL, clear, colorless to faint yellow or tan

痕量阳离子

Li: 3-4%

应用

diagnostic assay manufacturing
life science and biopharma
plasma purification
sample preparation

储存温度

room temp

SMILES字符串

[S](=O)(=O)(NC1C(OC(C(C1O)OC2OC(C(C(C2O[S](=O)(=O)O)O)OC)C(=O)O)CO[S](=O)(=O)O)OC)O

InChI

1S/C14H25NO20S3/c1-29-9-7(17)10(35-38(26,27)28)14(34-11(9)12(18)19)33-8-4(3-31-37(23,24)25)32-13(30-2)5(6(8)16)15-36(20,21)22/h4-11,13-17H,3H2,1-2H3,(H,18,19)(H,20,21,22)(H,23,24,25)(H,26,27,28)

InChI key

HXSDFQWQRCUQHF-UHFFFAOYSA-N

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一般描述

Heparin lithium is a highly sulfated polysaccharide that belongs to the family of glycosaminoglycans with remarkable significance in the areas of cell culture, cancer biology, biochemical, and drug discovery research. Due to its interactions with proteins and cells, it is used to study molecular and cellular processes, tumor modeling, investigate binding interactions, and as a cell culture supplement, to maintain cell viability.

应用

Heparin lithium was used:
  • To validate photometric measurements in cell surface charge determination
  • As an anti-coagulant for laboratory studies
  • To study hypothermal stress on lactate metabolism
  • To study the effects of anticoagulants in direct membrane feeding assays
  • For 2D and 3D vitro cell culture in glioblastoma cell models
  • To prevent clot formation and tissue damage during mechanical probing of cardiac pacemaker cell embryonic patterning, a study that contributes to the broader area of cardiac tissue mechanics research and developmental biology

特点和优势

  • Heparin with specific activity of ≥150 USP units/mg
  • Versatile and adaptable for a wide variety of laboratory and research applications

其他说明

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

从最新的版本中选择一种:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the potency of Product H0878, Heparin lithium salt from porcine intestinal mucosa?

    The specification for potency is ? 150 USP units/mg.  The lot specific potency can be found on the Certificate of Analysis, which can be accessed on the Product Detail page.

  4. How much heparin is needed to prevent coagulation in whole blood?

    Typically, between 20 and 50 units per mL of whole blood are needed.

  5. How can Product H0878, Heparin lithium salt from porcine intestinal mucosa be reconstituted?

    The solubility of heparin is 40 mg/mL in water.

  6. What is the solution stability of Product H0878, Heparin lithium salt from porcine intestinal mucosa?

    Heparin is a polysaccharide, which has excellent aqueous solution stability (up to 2 years at 2-8 °C) provided the solutions have been sterilized by filtration through a 0.2 μm membrane.  More solution stability information can be on the product information sheet (under Documents, above).

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

The effect of anticoagulants in blood collection tubes on Plasmodium falciparum transmission in direct membrane feeding assays
Wouter G et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 116, 187- 189 (2022)
Determination of cell surface charge by photometric titration
Thethi K et al
Journal of Biochemical and Biophysical Methods, 34, 137-145 (1997)
Chia-Hao Chang et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 248, 110744-110744 (2020-06-23)
The milkfish Chanos chanos, an economically important cultured marine species in Southeast Asia, exhibits stenothermal and euryhaline characteristics and huge mortality usually occurs during extreme cold weather in winter. Under conditions beyond optimal temperatures, ectothermic species experience an increase in
Beatriz Giesen et al.
Pharmaceutics, 13(2) (2021-03-07)
Gold nanoparticles (Au NPs) are studied as delivery systems to enhance the effect of the glutaminase1 inhibitor CB839, a promising drug candidate already in clinical trials for tumor treatments. Au NPs were synthesized using a bottom-up approach and covered with
R B Shartau et al.
The Journal of experimental biology, 223(Pt 7) (2020-03-05)
Acute (<96 h) exposure to elevated environmental CO2 (hypercarbia) induces a pH disturbance in fishes that is often compensated by concurrent recovery of intracellular and extracellular pH (pHi and pHe, respectively; coupled pH regulation). However, coupled pH regulation may be limited

商品

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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