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生物来源
human
质量水平
重组
expressed in E. coli
方案
≥80% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
185 kDa
包装
pkg of 100 μg
储存条件
avoid repeated freeze/thaw cycles
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... NRG1(3084)
相关类别
一般描述
Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.
生化/生理作用
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
外形
Solution in phosphate buffered saline containing 30% glycerol.
分析说明
Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Marcia R Campbell et al.
Cell reports, 38(5), 110291-110291 (2022-02-03)
Effective inactivation of the HER2-HER3 tumor driver has remained elusive because of the challenging attributes of the pseudokinase HER3. We report a structure-function study of constitutive HER2-HER3 signaling to identify opportunities for targeting. The allosteric activation of the HER2 kinase
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