所有图片(1)
别名:
Hygromycin B, Hygrovetine
经验公式（希尔记法）:
C20H37N3O13
CAS号:
分子量:
527.52
Beilstein:
6755837
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
生物来源
Streptomyces hygroscopicus
质量水平
无菌性
0.22 μm filtered
浓度
≥60% (HPLC)
45-60 mg/mL in H2O
颜色
brown-yellow
light orange to dark orange
light yellow to dark yellow
抗生素抗菌谱
viruses
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O
InChI
1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
InChI key
GRRNUXAQVGOGFE-XKIAHZFYSA-N
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相关类别
一般描述
Chemical structure: aminoglycoside
应用
Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.
生化/生理作用
抗菌剂和抗真菌剂。作用方式：在原核生物和真核生物中，通过诱导 mRNA 模板的误读而抑制蛋白质合成。它可选择性透入因病毒感染而变得可渗透的细胞。
注意
Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.
制备说明
This product is a solution that comes =60% (HPAE) and 45-60 mg/mL in H2O.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
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