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Merck
CN

H0654

潮霉素 B 溶液 来源于吸水链霉菌

≥60% (HPLC), 45-60 mg/mL in H2O

别名:

Hygromycin B, Hygrovetine

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关于此项目

经验公式（希尔记法）:
C20H37N3O13
化学文摘社编号:
31282-04-9
分子量:
527.52
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
24895410
MDL number:
MFCD06795479
Beilstein/REAXYS Number:
6755837

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产品名称

潮霉素 B 溶液 来源于吸水链霉菌, ≥60% (HPLC), 45-60 mg/mL in H2O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

SMILES string

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI key

GRRNUXAQVGOGFE-XKIAHZFYSA-N

biological source

Streptomyces hygroscopicus

sterility

0.22 μm filtered

concentration

≥60% (HPLC)
45-60 mg/mL in H2O

color

brown-yellow
light orange to dark orange
light yellow to dark yellow

antibiotic activity spectrum

viruses

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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相关类别

Biochem/physiol Actions

抗菌剂和抗真菌剂。作用方式：在原核生物和真核生物中，通过诱导 mRNA 模板的误读而抑制蛋白质合成。它可选择性透入因病毒感染而变得可渗透的细胞。

Application

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

Disclaimer

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

General description

Chemical structure: aminoglycoside

Preparation Note

This product is a solution that comes =60% (HPAE) and 45-60 mg/mL in H2O.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000419079
0000419077
0000419078
0000419079
0000419078

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