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CN
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安全信息

H0654

Sigma-Aldrich

潮霉素 B 溶液 来源于吸水链霉菌

≥60% (HPLC), 45-60 mg/mL in H2O

别名:

Hygromycin B, Hygrovetine

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About This Item

经验公式（希尔记法）:
C20H37N3O13
CAS号:
31282-04-9
分子量:
527.52
Beilstein:
6755837
MDL编号:
MFCD06795479
UNSPSC代码:
51102829
PubChem化学物质编号:
24895410
NACRES:
NA.85

生物来源

Streptomyces hygroscopicus

质量水平

200

无菌性

0.22 μm filtered

浓度

≥60% (HPLC)
45-60 mg/mL in H2O

颜色

brown-yellow
light orange to dark orange
light yellow to dark yellow

抗生素抗菌谱

viruses

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

InChI key

GRRNUXAQVGOGFE-XKIAHZFYSA-N

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相关类别

一般描述

Chemical structure: aminoglycoside

应用

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

生化/生理作用

抗菌剂和抗真菌剂。作用方式：在原核生物和真核生物中，通过诱导 mRNA 模板的误读而抑制蛋白质合成。它可选择性透入因病毒感染而变得可渗透的细胞。

注意

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

制备说明

This product is a solution that comes =60% (HPAE) and 45-60 mg/mL in H2O.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301 + H311,H330

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000354297
0000354298
0000354303
0000354303
0000354298

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