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安全信息

H0292

Sigma-Aldrich

HIV-1 Tat Peptide

≥97% (HPLC), lyophilized powder

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About This Item

经验公式（希尔记法）:
C64H118N32O14
CAS号:
191936-91-1
分子量:
1559.83
MDL编号:
MFCD07366706
UNSPSC代码:
12352202
PubChem化学物质编号:
329815111
NACRES:
NA.32

product name

HIV-1 Tat Protein (47-57),

生物来源

synthetic

质量水平

200

形式

lyophilized powder

溶解性

deionized water: soluble

运输

dry ice

储存温度

−20°C

SMILES字符串

NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C64H118N32O14/c65-25-3-1-11-39(89-50(101)38(13-5-27-81-59(69)70)88-48(99)34-87-49(100)37(67)33-35-19-21-36(97)22-20-35)51(102)90-40(12-2-4-26-66)52(103)91-41(14-6-28-82-60(71)72)53(104)92-43(16-8-30-84-62(75)76)55(106)95-45(23-24-47(68)98)57(108)94-42(15-7-29-83-61(73)74)54(105)93-44(17-9-31-85-63(77)78)56(107)96-46(58(109)110)18-10-32-86-64(79)80/h19-22,37-46,97H,1-18,23-34,65-67H2,(H2,68,98)(H,87,100)(H,88,99)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H,94,108)(H,95,106)(H,96,107)(H,109,110)(H4,69,70,81)(H4,71,72,82)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

InChI key

RAVVEEJGALCVIN-AGVBWZICSA-N

相关类别

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg

一般描述

HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule.

生化/生理作用

Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.

外形

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

其他说明

Lyophilized from 0.1% TFA in H2O

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
Campbell GR and Loret EP
Retrovirology, 6(1), 50-50 (2009)
The HIV-1 Tat protein enhances splicing at the major splice donor site
Mueller N, et al.
Journal of Virology, 92(14), e01855-e01817 (2018)
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
Charnay N, et al.
Retrovirology, 6(1), 74-74 (2009)
Roles and functions of HIV-1 Tat protein in the CNS: an overview
Bagashev A and Sawaya BE
Virology Journal, 10(1), 358-358 (2013)
Esteban Cruz et al.
Cancers, 11(6) (2019-06-27)
Nanoparticle carriers offer the possibility of enhanced delivery of therapeutic payloads in tumor tissues due to tumor-selective accumulation through the enhanced permeability and retention effect (EPR). Gold nanoparticles (AuNP), in particular, possess highly appealing features for development as nanomedicines, such

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