General description
Hartman固定剂，也称为Davidson固定剂，含有醋酸、酒精和福尔马林。它被广泛用于保存眼、骨髓、乳房、睾丸和其他组织以便组织学检查。
Application
用作根治性切除标本中淋巴结可视化的过夜固定剂。通过将淋巴结转变为白色，有助于乳房和结肠标本检查。Moore和Barr使用了一种Hartman固定剂来固定皮肤活检标本，用于研究细核细节。使用常规和改良的Hartman固定剂将大鼠睾丸固定24小时以用于免疫组织化学和形态学比较，而将用于其他分析的眼睛和睾丸标本固定48小时。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3
target_organs
Central nervous system, Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
75.2 °F
flash_point_c
24 °C
法规信息
危险化学品
此项目有
Fixation of testes and eyes using a modified Davidson's fluid: comparison with Bouin's fluid and conventional Davidson's fluid.
Latendresse J R, et al.
Toxicologic Pathology, 30(4), 524-533 (2002)
John R Latendresse et al.
Toxicologic pathology, 30(4), 524-533 (2002-08-22)
Most recent revisions of regulatory guidelines for testing effects of chemicals on reproduction recommend Bouin's fluid (BF) or a "comparable fixative" instead of formalin to preserve the morphologic detail of testes for histopathological evaluation. However, picric acid in BF is
Generation and functional characterization of a conditional Pumilio2 null allele.
Lin K, et al.
Journal of biomedical research (2017)
The sex chromatin in human malignant tissues.
K L MOORE et al.
British journal of cancer, 11(3), 384-390 (1957-09-01)
Dan Wang et al.
Biology of reproduction, 102(5), 1033-1044 (2020-02-11)
Fertilization is one of the fundamental biological processes, but so far, we still do not have a full understanding of the underlying molecular mechanism. We have identified a human acrosome protein, LY6/PLAUR domain containing 4 (LYPD4), expressed specifically in human
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