生物来源
bovine
质量水平
形式
lyophilized powder
技术
immunofluorescence: suitable
UniProt登记号
储存温度
−20°C
基因信息
cow ... VCAN(282662)
一般描述
Karl Meyer 和 John Palmer 首先从牛眼玻璃体中分离出透明质酸（HA）。他们创造了“透明质酸”这个名称，其是两个词的组合，透明体（玻璃质）和糖醛酸。HA在生理溶液中具有扩展的无规卷曲结构。由于其无规卷曲结构和高分子量（HMW），HA可形成非常粘的弹性溶液，具有巨大的流体动力学体积。
透明质酸（HA）是一种线性多糖，由具有1→4糖苷键的N-乙酰基-D-葡糖胺（GlcNAc）和D-葡萄糖醛酸（GlcA）的重复二糖组成，这些二糖重复单元又由β (1→3)链接。HA分子中重复的二糖数量范围为2,000至25,000个，对应于106-107的分子量。HA的独特生物学作用主要是由于其与HA结合蛋白（也称为透明质素）的特异性结合和相互作用。大多数透明质素由特定的结合域组成，也称为链接模块，由两个β-螺旋和两个反平行的β折叠组成。
应用
牛透明质酸结合蛋白可用于标本样品的培养，以用于人巨核细胞的免疫荧光分析。
生化/生理作用
HA不仅是所有脊椎动物组织的重要结构组成部分，而且还与包括细胞内信号转导在内的几种生物学功能有关。
透明质酸结合蛋白（HABP）的水平在卵母细胞成熟过程中增加，并在体外成熟过程中促进卵丘扩展。
可能用于透明质酸结合或检测中。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A G Haus
Radiologic clinics of North America, 25(5), 913-928 (1987-09-01)
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