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主要文件

H0161

Sigma-Aldrich

透明质酸结合蛋白 牛

lyophilized powder

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About This Item

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.56

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生物来源

bovine

质量水平

表单

lyophilized powder

技术

immunofluorescence: suitable

UniProt登记号

储存温度

−20°C

基因信息

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此商品
F0504M1891C4874
biological source

bovine

biological source

bovine milk

biological source

bovine

biological source

bovine

technique(s)

immunofluorescence: suitable

technique(s)

ligand binding assay: suitable, surface plasmon resonance (SPR): suitable

technique(s)

activity assay: suitable

technique(s)

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

P81282

UniProt accession no.

-

UniProt accession no.

P02687

UniProt accession no.

P62157

Gene Information

cow ... VCAN(282662)

Gene Information

-

Gene Information

cow ... MBP(618684)

Gene Information

bovine ... CALM(100297344)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

一般描述

Karl Meyer 和 John Palmer 首先从牛眼玻璃体中分离出透明质酸(HA)。他们创造了“透明质酸”这个名称,其是两个词的组合,透明体(玻璃质)和糖醛酸。HA在生理溶液中具有扩展的无规卷曲结构。由于其无规卷曲结构和高分子量(HMW),HA可形成非常粘的弹性溶液,具有巨大的流体动力学体积。
透明质酸(HA)是一种线性多糖,由具有1→4糖苷键的N-乙酰基-D-葡糖胺(GlcNAc)和D-葡萄糖醛酸(GlcA)的重复二糖组成,这些二糖重复单元又由β (1→3)链接。HA分子中重复的二糖数量范围为2,000至25,000个,对应于106-107的分子量。HA的独特生物学作用主要是由于其与HA结合蛋白(也称为透明质素)的特异性结合和相互作用。大多数透明质素由特定的结合域组成,也称为链接模块,由两个β-螺旋和两个反平行的β折叠组成。[1]

应用

牛透明质酸结合蛋白可用于标本样品的培养,以用于人巨核细胞的免疫荧光分析。[2]

生化/生理作用

HA不仅是所有脊椎动物组织的重要结构组成部分,而且还与包括细胞内信号转导在内的几种生物学功能有关。[1]
可能用于透明质酸结合或检测中。
透明质酸结合蛋白(HABP)的水平在卵母细胞成熟过程中增加,并在体外成熟过程中促进卵丘扩展。[3]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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    Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions
    Currao M, et al.
    Experimental Cell Research, 346(1), 1-8 (2016)
    A G Haus
    Radiologic clinics of North America, 25(5), 913-928 (1987-09-01)
    Today there are many dedicated mammographic x-ray units available that are capable of providing high-quality screen-film mammograms. Likewise, screen-film combinations designed for mammography are capable of providing images with appropriate contrast, resolution, and noise levels. Proper film processing is most
    Identification of hyaluronic acid-binding proteins and their expressions in porcine cumulus-oocyte complexes during in vitro maturation
    Yokoo M, et al.
    Biology of Reproduction, 67(4), 1165-1171 (2002)
    G Perides et al.
    The Journal of biological chemistry, 264(10), 5981-5987 (1989-04-05)
    A glial hyaluronate-binding protein (GHAP) with an isoelectric point of 4.3-4.4 was isolated from human brain white matter. The 60-kDa glycoprotein appeared to be quite resistant to proteolysis, and comparison with GHAP from a viable glioma removed at surgery showed
    Tal M Dankovich et al.
    Nature communications, 12(1), 7129-7129 (2021-12-10)
    The brain extracellular matrix (ECM) consists of extremely long-lived proteins that assemble around neurons and synapses, to stabilize them. The ECM is thought to change only rarely, in relation to neuronal plasticity, through ECM proteolysis and renewed protein synthesis. We

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