生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human, rat
制造商/商品名称
Genway 15-288-22829
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PSMC5(5705)
一般描述
PSMC5 (proteasome 26S subunit, ATPase, 5) is a regulatory subunit of the 26S proteasome belonging to the family of putative ATPases. It has structural homology with yeast Sug1p gene.
应用
Anti-PSMC5 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
26S protease regulatory subunit 8 is an enzyme encoded by the PSMC5 gene in humans and is important for the transcription of MHC II molecules. It has a role in regulating transcription of class I MHC and the MHC II-like molecules, HLA-DM and HLA-DO. PSMC5 acts as a key regulator of collagen contraction in primary human lung fibroblasts (a functional characteristic of myofibroblasts) and is a critical step in the process of fibrosis.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Michael F Nyp et al.
Respiratory research, 15, 19-19 (2014-02-18)
Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified Type II TGFβ receptor interacting protein 1 (TRIP-1), through proteomic analysis, as a key regulator
K Akiyama et al.
FEBS letters, 363(1-2), 151-156 (1995-04-17)
The nucleotide sequence of a cDNA that encodes a new regulatory subunit, named p45, of the 26S proteasome of human hepatoblastoma HepG2 cells has been determined. The polypeptide predicted from the open reading frame consists of 406 amino acid residues
Yaritza Inostroza-Nieves et al.
Immunology letters, 147(1-2), 67-74 (2012-07-10)
The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of
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