推荐产品
生物来源
chicken
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, human, rat
制造商/商品名称
Genway 15-288-22458A
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LDLR(3949)
应用
Anti-LDLR antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein encoded by the LDLR gene in humans and belongs to the low density lipoprotein receptor gene family. It is located on chromosome number 19. LDL receptor is a mosaic protein constituiting of exons shared with different proteins. It is crucial for maintenance of cholesterol homeostasis. A deficiency in LDLR leads to hypercholesterolemia. LDLR is a type I transmembrane protein that needs O-glycosylation for stable expression at the cell surface. Mutation in this gene may cause familial hypercholesterolemia (FH), an autosomal dominant disease.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Isabel De Castro-Orós et al.
BMC medical genomics, 7, 17-17 (2014-04-09)
GWAS have consistently revealed that LDLR locus variability influences LDL-cholesterol in general population. Severe LDLR mutations are responsible for familial hypercholesterolemia (FH). However, most primary hypercholesterolemias are polygenic diseases. Although Cis-regulatory regions might be the cause of LDL-cholesterol variability; an
Nis Borbye Pedersen et al.
The Journal of biological chemistry, 289(25), 17312-17324 (2014-05-07)
The low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis and deficiency in LDLR functions cause hypercholesterolemia. LDLR is a type I transmembrane protein that requires O-glycosylation for stable expression at the cell surface. It has previously been suggested
Jovan Nikolic et al.
Nature communications, 9(1), 1029-1029 (2018-03-14)
Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV. Here we report two crystal structures
Paulo Caleb Junior Lima Santos et al.
Atherosclerosis, 233(1), 206-210 (2014-02-18)
Familial hypercholesterolemia (FH) is an autosomal dominant disease caused mainly by LDLR mutations. This study assessed the influence of the presence and type of LDLR mutation on lipid profile and the response to lipid-lowering therapy in Brazilian patients with heterozygous
U Francke et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(9), 2826-2830 (1984-05-01)
The availability of a species-specific monoclonal antibody that recognizes the low density lipoprotein (LDL) receptor of human but not hamster origin permitted assignment of the structural gene for the human receptor to chromosome 19. The antibody was used to detect
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