GW21451
Anti-VAMP2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Vesicle-associated membrane protein 2
产品名称
Anti-VAMP2 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VAMP2(6844)
Application
Anti-VAMP2 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Vesicle-associated membrane protein 2 is a small integral membrane protein encoded by the VAMP2 gene in humans and is mapped on chromosome 17. It is a key component of the synaptic vesicle docking/fusion machinery and its mRNA. VAMP2 may be involved in the mechanism of action of antidepressants and may alter their efficacy. It is unlikely to play a major role in the efficacy of fluvoxamine. VAMP2 is recognized and cleaved by BoNT/B (Botulinum neurotoxin) and TeNT (tetanus neurotoxin) that possess similar organization.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Immunogen Sequence: GI # 7657675, sequence 43-93
Recombinant vesicle-associated membrane protein 2 (synaptobrevin 2)
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Eva Lasič et al.
Biochimica et biophysica acta, 1861(9), 2293-2303 (2017-07-04)
Dynamin is a multidomain GTPase exhibiting mechanochemical and catalytic properties involved in vesicle scission from the plasmalemma during endocytosis. New evidence indicates that dynamin is also involved in exocytotic release of catecholamines, suggesting the existence of a dynamin-regulated structure that
Sicai Zhang et al.
Nature communications, 8(1), 1637-1637 (2017-11-22)
Botulinum neurotoxins (BoNTs), the most potent toxins known, are potential bioterrorism agents. It is well established that all seven serotypes of BoNTs (BoNT/A-G) require complex gangliosides as co-receptors. Here, we report that BoNT/DC, a presumed mosaic toxin between BoNT/D and
Wankun L Li et al.
eLife, 7 (2018-03-14)
The rodent olfactory bulb incorporates thousands of newly generated inhibitory neurons daily throughout adulthood, but the role of adult neurogenesis in olfactory processing is not fully understood. Here we adopted a genetic method to inducibly suppress adult neurogenesis and investigated
Shinichi Saito et al.
Neuropsychobiology, 54(4), 226-230 (2007-03-16)
Vesicle-associated membrane protein 2 (VAMP2) is a key component of the synaptic vesicle docking/fusion machinery and its mRNA reportedly increases in the frontal cortex of rats following chronic antidepressant and electroconvulsive treatment. VAMP2 is therefore thought to be involved in
Sheng Chen et al.
The Journal of biological chemistry, 283(30), 21153-21159 (2008-05-31)
Botulinum neurotoxin (BoNT; serotypes A-G) and tetanus neurotoxin elicit flaccid and spastic paralysis, respectively. These neurotoxins are zinc proteases that cleave SNARE proteins to inhibit synaptic vesicle fusion to the plasma membrane. Although BoNT/B and tetanus neurotoxin (TeNT) cleave VAMP-2
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