推荐产品
生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MITF(4286)
一般描述
MITF (microphthalmia-associated transcription factor) is a b-HLH-Zip (basic helix-loop-helix leucine zipper) transcription factor, which is specific to melanocytes. It is a member of the Myc superfamily, and the gene is localized to human chromosome 3. It is 229kb in size. It belongs to the MiT (microphthalmia) family of transcription factors, which also includes TFEB (transcription factor EB), TFEC and TFE3. Due to alternative splicing, this protein is produced as multiple different isoforms such as TF-A, MITF-B, MITF-C, MITF-D, MITF-E, MITF-H, MITF-J, MITF-M and MITF-Mc. The N-termini of these isoforms vary, and they have different tissue expression patterns. The shortest isoform is MITF-M, which is only expressed in melanoma cells and melanocytes. Its transcriptional activity is modulated by its two TADs (transactivation domains), present at N- and C-termini.
免疫原
Immunogen Sequence: GI # 4557755, sequence 287-417
Recombinant microphthalmia-associated transcription factor isoform 4
应用
Anti-MITF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Microphthalmia-associated transcription factor (MITF) is involved in lineage-specific pathway regulation of many types of cells. Mitf is required for the proper development of osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. It can be a valuable adjunct in the diagnosis of metastatic tumors that are suspicious for melanoma but negative for other melanoma markers.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Ruifeng Guo et al.
International journal of clinical and experimental pathology, 6(8), 1658-1664 (2013-08-08)
Metastatic malignant melanoma has a wide spectrum of histopathologic patterns and often lacks melanin pigment. Without a known primary tumor, the diagnosis of metastatic malignant melanoma relies on a combination of morphology and immunohistochemical profile. Infrequently, commonly used markers for
Mariusz L Hartman et al.
Cellular and molecular life sciences : CMLS, 72(7), 1249-1260 (2014-12-01)
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-specific transcription factor whose role is profoundly extended in malignant melanoma. Over the last few years, the function of MITF has been tightly connected to plasticity of melanoma cells. MITF participates in executing
Christine L Hershey et al.
Bone, 34(4), 689-696 (2004-03-31)
The Microphthalmia-associated transcription factor (Mitf) is required for the proper development of several cell lineages including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. Mutations in Mitf in multiple organisms result in osteopetrosis due to defective
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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