生物来源
chicken
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
制造商/商品名称
Genway 15-288-21035
技术
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CCL4(6351)
一般描述
MIP-1β (macrophage inflammatory protein 1β) is a member of the CC chemokine (cysteine-cysteine) family, and is produced by monocytes and macrophages. This protein exists as a homodimer. It acts as a ligand to the GPCR (G-protein coupled receptor) called CCR5 (CC chemokine receptor 5).
免疫原
Immunogen Sequence: GI # 4506845, sequence 27-92
Recombinant chemokine C-C motif ligand 4 isoform 1
应用
Anti-MIP-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Chemokine (C-C motif) ligand 4 (CCL4) is a principal regulator of macrophage migration and signals through CCR5. CCR5 is linked to several protein kinases including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2 and members of the MAPK family that help in regulating macrophage chemotaxis. CCL4 is released at the site of inflammation in sarcoidosis.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
A Barczyk et al.
International journal of immunopathology and pharmacology, 27(2), 185-193 (2014-07-10)
Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis
Melissa A McCornack et al.
The Journal of biological chemistry, 278(3), 1946-1956 (2002-11-02)
Chemokines comprise a family of proteins that function in the immune response to recruit leukocytes to sites of infection. This recruitment is believed to be carried out by the establishment of a chemokine gradient by the binding of chemokines to
Li Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(38), 13985-13990 (2006-09-12)
Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high
Ricky Cheung et al.
Journal of leukocyte biology, 86(4), 833-845 (2009-07-22)
MIP-1beta/CCL4 is a principal regulator of macrophage migration and signals through CCR5. Several protein kinases are linked to CCR5 in macrophages including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2, and members of the MAPK family, but whether
Isaac G Sakala et al.
Infection and immunity, 81(6), 1974-1983 (2013-03-20)
Tuberculosis remains one of the top three leading causes of morbidity and mortality worldwide, complicated by the emergence of drug-resistant Mycobacterium tuberculosis strains and high rates of HIV coinfection. It is important to develop new antimycobacterial drugs and immunomodulatory therapeutics
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