推荐产品
生物来源
chicken
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
rat, human, mouse
制造商/商品名称
Genway 15-288-20083F
技术
western blot: suitable
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IGHG1(3500)
免疫原
IgG Fc 人天然蛋白。
应用
抗人 IgG（Fc 特异性）抗体（鸡来源）适用于蛋白质印迹分析（1：500 稀释），也适用于组织或细胞染色（1：200 稀释）。
生化/生理作用
Ig γ-1链C区是人IGHG1基因编码的蛋白。Ig γ-1链C区存在于人胰腺癌组织中，在邻近的非癌组织中表达极低。阻断IGHG1可延缓肿瘤生长、提高生存率。它在胰腺癌细胞中的存在可能是参与肿瘤细胞增殖和免疫逃避机制的重要因素。IGHG1与前列腺癌相关，可抑制细胞活力，从而导致细胞凋亡。它是前列腺癌基因治疗的潜在靶点。
外形
含有 0.02％ 叠氮化钠的磷酸盐缓冲盐水溶液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Judith Blaine
Methods in molecular biology (Clifton, N.J.), 2224, 123-132 (2021-02-20)
Proteinuria is a widely used marker of renal disease and is strongly associated with renal and cardiovascular outcomes. The molecular mechanisms underlying filtration of serum proteins through the glomerular filtration barrier (GFB) remain to be determined. Since the GFB is
Bin Pan et al.
Molecular biology reports, 40(1), 27-33 (2012-11-03)
To investigate the immunoglobulin G (IgG) expression in prostate cancer cell lines and explore the effects of IGHG1 gene knockdown on PC3 cell growth and apoptosis. Flow cytometry, qPCR and western blot were used to demonstrate IgG expression in prostate
Xiaoyan Li et al.
Pancreas, 40(5), 753-761 (2011-06-10)
To investigate the expression of Igγ-1 chain C region (IGHG1) in human pancreatic carcinomas and determine the biological function of IGHG1 expression in immune evasion mechanisms. Comparative proteomic analysis was used to detect the differential expression of IGHG1 in human
James Dylewski et al.
PloS one, 14(2), e0209732-e0209732 (2019-02-28)
Proteinuria is strongly associated with kidney disease progression but the mechanisms underlying podocyte handling of serum proteins such as albumin and IgG remain to be elucidated. We have previously shown that albumin and IgG are transcytosed by podocytes in vitro.
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