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生物来源
human
质量水平
重组
expressed in E. coli
方案
>95% (SDS-PAGE)
表单
frozen liquid
比活
60.45 units/mg protein
分子量
23 kDa
储存温度
−70°C
基因信息
human ... GSTP1(2950)
一般描述
using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1.0 mM) in 100 mM KPO4 (pH 6.5) at room temperature.
生化/生理作用
Glutathione S-transferase pi 1 (GSTP1) is an enzyme that in humans is encoded by the GSTP1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
储存及稳定性
The enzyme should be used by the end-user customer within 1 year of receipt.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Junhua Wu et al.
PloS one, 10(6), e0128280-e0128280 (2015-06-06)
Brick tea type fluorosis is a public health concern in the north-west area of China. The association between SNPs of genes influencing bone mass and fluorosis has attracted attention, but the association of SNPs with the risk of brick-tea type
J Haluskova et al.
Bratislavske lekarske listy, 116(2), 79-82 (2015-02-11)
Prostate cancer (PCa) represents one of the most complicated human tumors and, like many others malignancies, arises from progressive genetic and epigenetic alterations. Among all recognized epigenetic alterations, aberrant DNA methylation (hypo- and hypermethylation) is the most important and the
Q F Li et al.
Genetics and molecular research : GMR, 14(2), 6762-6772 (2015-07-01)
Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching
Cheng-Fan Zhou et al.
Archives of dermatological research, 307(6), 505-513 (2015-06-06)
Numerous epidemiological studies have evaluated the association of Glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with the risk of skin cancer. However, the results remain inconclusive. To derive a more precise estimation of the association between the GSTP1 Ile105Val polymorphism and
Mohamad Nidal Khabaz et al.
Asian Pacific journal of cancer prevention : APJCP, 16(5), 1707-1713 (2015-03-17)
Eighty six cases of invasive ductal breast carcinomas were utilized to investigate GSTP1 polymorphisms in certain immunohistochemistry (IHC) subtypes of breast cancer with respect to ER, PR and HER2 expression. The frequency of wild allele homozygote, heterozygote and variant allele
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