形式
solid
包装
pack of 1000 U
制造商/商品名称
Cytiva E70092Z
运输
dry ice
储存温度
−20°C
相关类别
一般描述
Shrimp alkaline phosphatase is a high specific activity, heat-labile alkaline phosphatase. Completely and irreversibly inactivated in Tris buffers at pH 8.0 to 8.5 by heating for 15 min at 65°C. No further treatment is necessary. The ALP (alkaline phosphatase) gene codes for a membrane-bound ectoenzymes that is present in four isoforms and is distributed as tissue nonspecific, intestinal, placenta, and germ cell ALP. The tissue nonspecific enzyme is ubiquitously expressed in a variety of tissues including liver, bone, kidney and is predominant in osteoblasts. Alkaline phosphatase is also known as mesenchymal stem cell antigen 1 or tissue nonspecific alkaline phosphatase.
生化/生理作用
Alkaline phosphatase hydrolyses pyrophosphate (PPi) to inorganic phosphate and thus maintains a balance between the two forms of phosphate which is highly essential for mineralization. Higher levels of serum alkaline phosphatase is found in prostate cancer. Severe TNAP deficiency refers to hypophosphatasia characterized with defective pyridoxal 5′-phosphate metabolism and skeletal hypomineralization.
特点和优势
- Removing 5′-phosphates from DNA and RNA.
- Easily inactivated by heat.
储存及稳定性
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
分析说明
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
法规信息
新产品
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer.
Rao S R, et al.
British Journal of Cancer, 116(2), 227-227 (2017)
The mechanism of mineralization and the role of alkaline phosphatase in health and disease.
Orimo H
Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi, 77(1), 4-12 (2010)
Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC.
Jin H, et al.
Science Signaling, 9(458), ra121-ra121 (2016)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门