推荐产品
包装
pack of 2500 U
制造商/商品名称
Cytiva E70073Z
运输
dry ice
储存温度
−20°C
一般描述
Exonuclease I.
The EXO1 (exonuclease I) gene is mapped to human chromosome 1q43 and codes for a 5′→3′ exonuclease of 846 amino acids. It belongs to the 5′-nuclease superfamily.
应用
Acts specifically on single-stranded DNA degrading it processively in the 3′- to 5′-direction, producing 5′-mononucleotides.
生化/生理作用
Exonuclease I (EXO1) maintains genomic stability by participating in DNA mismatch repair system, DNA recombination, DNA replication and DNA double-stranded break repair in eukaryotes. It also modulates meiosis, immunoglobulin maturation, and micro-mediated end-joining. It functions on DNA with blunt, nicked, gapped and 3′-overhangs. It also possesses endonuclease action and removes 5′-single-stranded flaps that protrudes from a double stranded DNA. Mutation in EXO1 gene results in increased susceptibility to develop cancer.
特点和优势
- Eliminating residual single-stranded DNA containing a 3′-terminus.
- Measuring endonucleolytic cleavage of covalently closed circular (ccc) ssDNA.
- Measuring DNA helicase activity.
储存及稳定性
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
分析说明
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
储存分类代码
12 - Non Combustible Liquids
法规信息
新产品
Human Exonuclease 1 Threads 5?-Flap Substrates through Its Helical Arch.
Shaw S J, et al.
Biochemistry, 56(29), 3704-3707 (2017)
Exonuclease 1 and its versatile roles in DNA repair.
Keijzers G, et al.
Critical Reviews in Biochemistry and Molecular Biology, 51(6), 440-451 (2016)
Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma.
Tan S, et al.
Oncotarget, 7(52), 87180-87180 (2016)
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