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Merck
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安全信息

G9923

Sigma-Aldrich

胡黄连苷I

≥98% (HPLC)

别名:

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside 6-[(2E)-3-phenyl-2-propenoate], 6′-Cinnamoylcatalpol

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About This Item

经验公式（希尔记法）:
C24H28O11
CAS号:
27409-30-9
分子量:
492.47
EC 号:
248-445-1
MDL编号:
MFCD29505480
UNSPSC代码:
12352205
NACRES:
NA.25
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质量水平

200

方案

≥98% (HPLC)

溶解性

ethanol: 1 mg/mL, clear, colorless

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

2-8°C

SMILES字符串

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(/C=C/C2=CC=CC=C2)=O)O[C@H]1O[C@@H]3OC=C[C@]4([H])[C@@]3([H])[C@](O5)(CO)[C@@H]5[C@H]4O

InChI

1S/C24H28O11/c25-11-24-16-13(17(27)21(24)35-24)8-9-31-22(16)34-23-20(30)19(29)18(28)14(33-23)10-32-15(26)7-6-12-4-2-1-3-5-12/h1-9,13-14,16-23,25,27-30H,10-11H2/b7-6+/t13-,14-,16-,17+,18-,19+,20-,21+,22+,23+,24-/m1/s1

InChI key

XZGPUOQGERGURE-LUVHZPKESA-N

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HTS112MHTS170MHTS099M
ChemiSCREEN Membrane Preparation Recombinant Human GLP-1 Human GLP-1 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.

HTS163M

ChemiSCREEN Membrane Preparation Recombinant Human GLP-1

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HTS112M

ChemiScreen Recombinant Human Glucagon Receptor Membrane Preparation

ChemiSCREEN Membrane Preparation Recombinant Human sst1 Somatostatin Receptor Human sst1 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.

HTS170M

ChemiSCREEN Membrane Preparation Recombinant Human sst1 Somatostatin Receptor

ChemiSCREEN Membrane Preparation Recombinant Human EP1 Prostanoid Receptor Human EP1 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.

HTS099M

ChemiSCREEN Membrane Preparation Recombinant Human EP1 Prostanoid Receptor

recombinant

expressed in Chem-9 cells

recombinant

expressed in Chem-1 cells

recombinant

expressed in Chem-1 cells

recombinant

expressed in Chem-1 cells

manufacturer/tradename

ChemiScreen

manufacturer/tradename

ChemiScreen, Chemicon®

manufacturer/tradename

ChemiScreen, Chemicon®

manufacturer/tradename

ChemiScreen, Chemicon®

technique(s)

ligand binding assay: suitable (GTPγS)

technique(s)

ligand binding assay: suitable (GTPγS), radioligand binding assay (RLBA): suitable

technique(s)

ligand binding assay: suitable (GTPγS), radioligand binding assay (RLBA): suitable

technique(s)

ligand binding assay: suitable (GTPγS), radioligand binding assay (RLBA): suitable

NCBI accession no.

NM_002062.2

NCBI accession no.

NM_000160.2

NCBI accession no.

NM_000868

NCBI accession no.

NM_000955

UniProt accession no.

P43220

UniProt accession no.

P47871

UniProt accession no.

P30872

UniProt accession no.

P34995

一般描述

Picroside I is one of the major phytochemicals found in the roots and rhizomes of Picrorhiza kurroa Royle ex Benth.

生化/生理作用

Phytochemical found within a Traditional Chinese Medicine herbal preparation. Picroside I, an iridoid glycoside, is a hepatoprotective agent.
Picroside I is a potent anti-cancer, antioxidant, and anti-inflammatory agent. Picroliv is a standardized drug that is a mixture of two iridoid glycoside components picroside I and picroside II (Kutkoside). It displays protection against ischemia-reperfusion injury, respiratory, and inflammatory diseases.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000224552
    SLCQ4414
    0000224552
    SLBN3608V
    SLBC6345V

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    M L Brown
    AANA journal, 60(1), 33-40 (1992-02-01)
    A prospective study was undertaken in an effort to determine the usefulness of the end-tidal carbon dioxide monitor in detecting anesthesia-related critical incidents. The critical incident technique was employed in the evaluation of 2,334 anesthetics. Anesthesia providers completed a critical
    Deepika Soni et al.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1680-1687 (2018-12-16)
    The steady rise in life expectancy, modern life style and changing environmental conditions are responsible for increasing incidence of cancer. A number of chemical drugs have been used for cancer treatment; however the induction of genotoxic, carcinogenic and teratogenic effects
    P Li et al.
    Biological & pharmaceutical bulletin, 23(7), 890-892 (2000-08-05)
    A crude methanol extract of Picrorhizae Rhizoma, the dried underground parts of Picrorhiza scrophulariiflora PENNELL, has been shown to potentiate the nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells. The methanol extract was partitioned between ethyl acetate and water.
    P Li et al.
    European journal of pharmacology, 406(2), 203-208 (2000-10-06)
    Natural iridoid, picroside I (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1, 2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate)) or II (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl )ox ireno[4,5]cyclopenta[1,2-c]pyran-2-yl) alone did not exhibit neuritogenic activity, but caused a concentration-dependent (>0.1 microM) enhancement of nerve growth factor (NGF, 2 ng/ml)-induced neurite outgrowth from PC12D
    Parul Gahlan et al.
    BMC genomics, 13, 126-126 (2012-04-03)
    Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids picroside I and II, which are modulated by temperature. The transcriptome information of this species is limited with the availability
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