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产品名称
胶霉毒素 来源于胶霉,
质量水平
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
InChI
1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChI key
FIVPIPIDMRVLAY-RBJBARPLSA-N
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一般描述
Chemical structure: epipolythiodioxopiperazine
Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.
应用
Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.
Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro.
生化/生理作用
Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
On the cytotoxicity of some microbial volatile organic compounds as studied in the human lung cell line A549
Kreja L and Seidel HJ
Chemosphere, 49(1), 105 -1110 (2002)
Gliotoxin and related epipolythiodioxopiperazines
Waring P and Beaver J
General Pharmacology, 27(8), 1311-1316 (1996)
Aspergillus mycotoxins and their effect on the host
Kamei K and Watanabe A
Medical Mycology, 43(sup1), 95 -999 (2005)
Larissa Anastacio da Costa Carvalho et al.
Antioxidants (Basel, Switzerland), 13(5) (2024-05-25)
Microenvironment and transcriptional plasticity generate subpopulations within the tumor, and the use of BRAF inhibitors (BRAFis) contributes to the rise and selection of resistant clones. We stochastically isolated subpopulations (C1, C2, and C3) from naïve melanoma and found that the
Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
Stanzani M, et al.
Blood, 105(6), 2258 -22265 (2005)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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