生物来源
human plasma
质量水平
检测方案
≥99% (agarose gel electrophoresis)
形式
powder
技术
ELISA: suitable
杂质
HIV-1/HIV-2, HCV and hepatitis B antigen, tested negative
UniProt登记号
储存温度
2-8°C
基因信息
human ... ORM1(5004)
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相关类别
一般描述
α-1-酸性糖蛋白（AGP）/血清类粘蛋白（ORM），一种糖蛋白，分子量为 41-43kDa。它被认为是人和大鼠中重要的急性期蛋白之一。AGP 可能属于脂质运载蛋白家族。
应用
α人血浆中的 1-酸性糖蛋白已用于：
- 作为带负电荷的蛋白，以研究在聚电解质多层表面上的吸附过程
- 在研究中孵育涂有纯化抗血清的平板，以通过 ELISA 研究其血清浓度
- 研究不同浓度对人免疫缺陷病毒（HIV）蛋白酶抑制剂的抗病毒活性的影响
生化/生理作用
α1-酸性糖蛋白具有免疫调节作用。它能结合酸性药物（例如苯巴比妥）。
制备说明
从科恩级分 VI 纯化
免责声明
仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
In Vitro Effect of alpha1-Acid Glycoprotein on the Anti?Human Immunodeficiency Virus (HIV) Activity of the Protease Inhibitor CGP 61755: A Comparative Study with Other Relevant HIV Protease Inhibitors
Lazdins J K, et al.
The Journal of Infectious Diseases, 175(5), 1063-1070 (1997)
Hendrik Grootaert et al.
Glycobiology, 30(9), 735-745 (2020-03-10)
The deoxy sugar l-fucose is frequently found as a glycan constituent on and outside living cells, and in mammals it is involved in a wide range of biological processes including leukocyte trafficking, histo-blood group antigenicity and antibody effector functions. The
Chenhua Zhang et al.
Analytica chimica acta, 1078, 189-199 (2019-07-31)
Silica-based lectin microcolumns were developed and optimized for the separation and analysis of glycoform fractions in alpha1-acid glycoprotein (AGP) based on both the degree of branching and level of fucosylation. Concanavalin A (Con A) and Aleuria Aurantia lectin (AAL) were
Jae Woong Choi et al.
Journal of microbiology and biotechnology, 30(9), 1297-1304 (2020-07-07)
Elevated serum levels of alpha-1-acid glycoprotein (AGP) are known to be associated with several types of cancer. In addition, some reports have indicated that changes in glycosylation of AGP are associated with cancer progression. However, changes in AGP levels of
Development of large-scale fractionation methods. IV. A simple method for the large-scale preparation of alpha1-acid glycoprotein.
Y L Hao et al.
Biochimica et biophysica acta, 322(1), 99-108 (1973-09-21)
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