一般描述
Research area: Cell Signaling
Glutamic-pyruvic transaminase (GPT) is located in most cells in the body but is found in highest concentrations in the liver. Two GPT isoforms, GPT1 and GPT2, are present in mammals.
Glutamic-pyruvic transaminase (GPT) is located in most cells in the body but is found in highest concentrations in the liver. Two GPT isoforms, GPT1 and GPT2, are present in mammals.
应用
Glutamic-Pyruvic Transaminase from porcine heart has been used to determine L-lactate levels in aqueous polyethylene glycol (PEG) solutions.
生化/生理作用
GPT is responsible for catalyzing the reversible transamination of α-ketoglutarate and alanine to glutamate and pyruvate. It also plays a critical role in the metabolism of amino acids and gluconeogenesis.
谷丙转氨酶 (GPT) 存在于体内大多数细胞中，但在肝脏中浓度最高。由于在肝细胞坏死后 GPT 释放入血液，可作为肝脏疾病的标志物。
单位定义
一个单位在37℃和pH 7.6，L-丙氨酸存在条件下将1.0μmole α酮戊二酸转化成L-谷氨酸。
外形
1.8M (NH4)2SO4 溶液中的悬浮液，pH 6.0
分析说明
由缩二脲确定的蛋白质。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Glutamic-Pyruvic Transaminase 1 Facilitates Alternative Fuels for Hepatocellular Carcinoma Growth?A Small Molecule Inhibitor, Berberine
Guo W, et al.
Cancers, 12(7), 1854-1854 (2020)
Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency
Benit P, et al.
EBioMedicine, 17, 75?87-75?87 (2017)
Xing-Fei Pan et al.
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 26(6), 477-479 (2013-05-01)
To investigate the level of the serum IL-21 and its correlation with serum biochemical indices of liver function test in patients with acute-on-chronic liver failure. Sixty patients with acute-on-chronic liver failure (severe hepatitis group) and 18 normal cases (control group)
Biochemical Methods to Assess the Coupling of Brain Energy Metabolism in Control and Disease States
Zechel J, et al.
Journal of Separation Science, 79?98-79?98 null
Martin J J Ronis et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 151-162 (2013-04-12)
Metabolic syndrome is often accompanied by development of hepatic steatosis and less frequently by non-alcoholic fatty liver disease (NAFLD) leading to non-alcoholic steatohepatitis (NASH). Replacement of corn oil with medium chain triacylglycerols (MCT) in the diets of alcohol-fed rats has
商品
以硫酸铵悬浮液形式提供的酶的使用指南
Instructions for working with enzymes supplied as ammonium sulfate suspensions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门