G9548
光甘草定
≥98% (HPLC), powder, isoflavan
别名:
4-[(3R)-3,4-二氢-8,8-二甲基-2H,8H-苯并 [1,2-b:3,4-b′] 二吡喃-3-基]-1,3-苯二酚, 光甘草定, (R)-4-（3,4-二氢-8,8-二甲基-2 H,8 H-苯并 [1,2-b:3,4-b'] 二吡喃-3-基）-1,3-苯二酚
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所有图片(1)
About This Item
经验公式（希尔记法）:
C20H20O4
CAS号:
分子量:
324.37
Beilstein:
7141956
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
产品名称
光甘草定, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c4ccc(O)cc4O
InChI
1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChI key
LBQIJVLKGVZRIW-ZDUSSCGKSA-N
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应用
光甘草定已被用于：
- 分析其在健康志愿者血浆中的转甲状腺素蛋白（TTR）稳定作用
- 作为质子核磁共振（1H NMR）中的标准品用于通过多光谱和分子对接（multi-spectroscopic and molecular docking ）技术研究光甘草定和人血清球蛋白的相互作用
- 研究其对核苷酸结合寡聚化结构域样受体Pyrin域蛋白3（NLRP3）炎症小体活化的作用
生化/生理作用
光甘草定是glavonoid 的主要成分，也称为来源于甘草的黄酮油，是用于传统医学和草药的天然增补剂。
光甘草定是一种可生物利用的异黄烷，是从甘草（洋甘草 ）根部提取物分离而来。据报道光甘草定具有多种生物活性，包括强抗氧化活性、 抗 LDL 氧化活性、抗-幽门螺旋杆菌性质、类雌激素活性和自由基清除活性。 它也可以抑制血清素再摄取、黑素生成、发炎和细胞色素P450、3A4、2B6和2C9。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin
Razzak MA, et al.
Food Hydrocolloids, 91, 290-300 (2019)
H-S Kwon et al.
Clinical and experimental immunology, 151(1), 165-173 (2007-11-17)
Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The aims of this study were to determine whether oral administration of glabridin, a functional component of liquorice, could
Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans.
Fumiki Aoki et al.
Journal of the American College of Nutrition, 26(3), 209-218 (2007-07-20)
Licorice flavonoids have various physiological activities such as abdominal fat-lowering, hypoglycemic and antioxidant effects. Licorice flavonoid oil (LFO: Kaneka Glavonoid Rich Oil) is a new dietary ingredient containing licorice flavonoids dissolved in medium-chain triglycerides (MCT). Glabridin is one of the
A novel fluorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors
Ye Y, et al.
Sensors and Actuators B, Chemical, 301, 126864-126864 (2019)
Hiroaki Matsushita et al.
Heliyon, 7(10), e08101-e08101 (2021-10-26)
Transthyretin (TTR) is an amyloidogenic protein associated with hereditary and nonhereditary transthyretin amyloidoses (ATTR). Dissociation of the tetramer of TTR to the monomer induces TTR misfolding, which leads to amyloid fibril formation and triggers the onset of ATTR amyloidosis. Stabilizers
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