一般描述
γ-谷氨酰转肽酶是一种异二聚酶，属于N端亲核水解酶超家族。
应用
来自马肾的γ-谷氨酰转肽酶已用于：
- 鉴定河豚肝脏中4-S-半胱氨酸河豚毒素的形成
- 作为标准品，用于测定人B细胞淋巴瘤细胞裂解物的γ -谷氨酰转移酶的活性
- 解异肽，以研究其对微管蛋白聚集的影响
生化/生理作用
γ-谷氨酰转肽酶参与谷胱甘肽代谢，可以催化γ -谷氨酰化合物的裂解，如谷胱甘肽。它还对γ -谷氨酰基向氨基酸和多肽的转移发挥着作用。
质量
粗品
单位定义
在 25°C、pH 8.5 的条件下，一个单位每分钟从 L-γ-谷氨酰-β-硝基苯胺中释放出 1.0 μmol 对硝基苯胺。
抑制剂
产品编号
说明
价格
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Gina Boanca et al.
The Journal of biological chemistry, 281(28), 19029-19037 (2006-05-05)
Gamma-glutamyltranspeptidase (gammaGT), a member of the N-terminal nucleophile hydrolase superfamily, initiates extracellular glutathione reclamation by cleaving the gamma-glutamyl amide bond of the tripeptide. This protein is translated as an inactive proenzyme that undergoes autoprocessing to become an active enzyme. The
Lawrence M Schopfer et al.
The Journal of biological chemistry, 293(35), 13566-13577 (2018-07-15)
Exposure to organophosphorus toxicants (OP) can have chronic adverse effects that are not explained by inhibition of acetylcholinesterase, the cause of acute OP toxicity. We therefore hypothesized that OP-induced chronic illness is initiated by the formation of organophosphorus adducts on
Karin Bracht et al.
Journal of cancer research and clinical oncology, 133(12), 957-967 (2007-06-15)
The aim of this study was to characterize three new, recently established non-Hodgkin lymphoma cell lines (GUMBUS, DOGUM, and DOGKIT), isolated from patients developing high-clinical resistance to cytotoxic therapy, with respect to sensitivity toward 21 antitumor drugs from different classes
H Suzuki et al.
Amino acids, 32(3), 333-340 (2006-10-13)
Some amino acids and peptides, which have low solubility in water, become much more soluble following gamma-glutamylation. Compounds become more stable in the blood stream with gamma-glutamylation. Several gamma-glutamyl compounds are known to have favorable physiological effects on mammals. Gamma-glutamylation
Mari Yotsu-Yamashita et al.
Chemical research in toxicology, 18(5), 865-871 (2005-05-17)
The metabolic pathway of tetrodotoxin (TTX), a powerful and specific voltage-gated sodium channel blocker, has not been well-clarified either in TTX-poisoned patients or in puffer fish. 4-S-CysteinylTTX (4-CysTTX) was isolated from the liver of the puffer fish, Fugu pardalis, as
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