所有图片(1)
别名:
2，2＆＃8242;-[[二氢-2-（4-吡啶基）-1，3-（2H，4H）-嘧啶二基]双（亚甲基）]双[N，N-二甲基苯胺, NSC 136476
经验公式（希尔记法）:
C27H35N5
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to off-white
溶解性
DMSO: >2 mg/mL
储存温度
2-8°C
InChI
1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
InChI key
KVQOGDQTWWCZFX-UHFFFAOYSA-N
生化/生理作用
GANT61 通过抑制 Gli1 的转录活性阻断 hedgehog 通路信号转导（IC50 =5 μM）。 在裸鼠中，GANT 61 可导致 22Rv1 人前列腺肿瘤细胞异种移植缩小。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Syeda Kiran Riaz et al.
Scientific reports, 9(1), 6620-6620 (2019-05-01)
Sonic Hedgehog signaling is critical for breast morphogenesis and cancer. The present study was conducted to explore the influence of SHH/GLI1 axis on epithelial mesenchymal transition and invasion in breast cancer cells. SHH/GLI1 positive samples demonstrated high expression of Snail
Syeda Kiran Riaz et al.
Frontiers in cell and developmental biology, 9, 758400-758400 (2021-11-02)
The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients. The current study aimed to identify FGFR1-linked genes to devise
Taghi Manshouri et al.
Cell death & disease, 13(5), 481-481 (2022-05-21)
Bone marrow (BM) fibrosis was thought to be induced exclusively by mesenchymal stromal cells (MSCs). However, we and others found that neoplastic fibrocytes induce BM fibrosis in myelofibrosis (MF). Because glioma-associated oncogene-1 (GLI1), an effector of the Hedgehog pathway, plays
Yonghong Hu et al.
Frontiers in pharmacology, 13, 1033103-1033103 (2022-12-10)
Backgroud and aims: Ductular reaction (DR) is a common pathological change and thought to have a key role in the pathogenesis and progression of liver fibrosis. Our previous study reported Gypenosides (GPs) ameliorated liver fibrosis, however, the anti-fibrotic mechanisms of
Wenjie Zhang et al.
Oncology letters, 15(4), 5155-5160 (2018-03-20)
As a novel member of the Rab GTPase family, the role of Rab23 has been reported in multiple types of tumor. However, to the best of our knowledge, the role of Rab23 in ovarian cancer (OC) has not yet been
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