推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 78 kDa
种属反应性
mouse, hamster, human
增强验证
independent
Learn more about Antibody Enhanced Validation
技术
immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells
microarray: suitable
western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HSPA5(3309)
mouse ... Hspa5(14828)
相关类别
一般描述
GRP78/BiP is a Ca2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.
应用
Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
生化/生理作用
GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress
Ouyang YB, et al.
Mitochondrion, 11(2), 279-286 (2011)
Eva Ramon et al.
The Journal of biological chemistry, 289(52), 35918-35928 (2014-11-02)
Retinitis pigmentosa (RP) is a group of genetically and clinically heterogeneous inherited degenerative retinopathies caused by abnormalities of photoreceptors or retinal pigment epithelium in the retina leading to progressive sight loss. Rhodopsin is the prototypical G-protein-coupled receptor located in the
Mina Thon et al.
Scientific reports, 6, 34312-34312 (2016-09-30)
Leptin, an adipocyte-derived hormone, centrally regulates energy homeostasis. Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. However, the effects of insulin on leptin's actions in the central nervous system (CNS) have not
GRP78 at the centre of the stage in cancer and neuroprotection
Casas, Caty
Frontiers in Neuroscience, 11, 177-177 (2017)
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease
Wang WX, et al.
The American Journal of Pathology, 177(1), 334-345 (2010)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门