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Merck
CN

G8918

Anti-GRP78/BiP (GL-19) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

别名:

Anti-78-kDa Glucose-Regulated Protein, Anti-Immunoglobulin Heavy Chain Binding Protein

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01865530

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产品名称

Anti-GRP78/BiP (GL-19) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 78 kDa

species reactivity

mouse, hamster, human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells
microarray: suitable
western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract

UniProt accession no.

P11021

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HSPA5(3309)
mouse ... Hspa5(14828)

相关类别

Application

Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:
  • western blotting
  • immunocytochemistry
  • immunohistochemistry

Biochem/physiol Actions

GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

GRP78/BiP is a Ca2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000475637
0000475637
0000440297
0000440297
0000396602

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GRP78 at the centre of the stage in cancer and neuroprotection
Casas, Caty
Frontiers in Neuroscience, 11, 177-177 (2017)
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease
Wang WX, et al.
The American Journal of Pathology, 177(1), 334-345 (2010)
Mina Thon et al.
Scientific reports, 6, 34312-34312 (2016-09-30)
Leptin, an adipocyte-derived hormone, centrally regulates energy homeostasis. Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. However, the effects of insulin on leptin's actions in the central nervous system (CNS) have not
Henning G Hansen et al.
Bioscience reports, 34(2) (2014-04-01)
In the ER (endoplasmic reticulum) of human cells, disulfide bonds are predominantly generated by the two isoforms of Ero1 (ER oxidoreductin-1): Ero1α and Ero1β. The activity of Ero1α is tightly regulated through the formation of intramolecular disulfide bonds to help
BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation
Brennan LA, et al.
Experimental Eye Research, 174, 173-184 (2018)
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Data Sheet - G8918

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