G8913
抗谷氨酸受体NMDAR1（NR1） 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
Anti-GluN1, Anti-MRD8, Anti-NDHMSD, Anti-NDHMSR, Anti-NMD-R1, Anti-NMDA1, Anti-NMDAR1, Anti-NR1
产品名称
抗谷氨酸受体NMDAR1（NR1） 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 116 kDa
species reactivity
rat, human, mouse
packaging
antibody small pack of 25 μL
technique(s)
western blot: 1:2,000 using extract of a rat brain synaptosomal fraction.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)
Biochem/physiol Actions
N-甲基-D-天冬氨酸受体1（NMDAR1）可调节兴奋性突触传递。该受体的功能异常与癫痫和精神分裂症有关。
Application
兔谷氨酸受体NMDAR1（NR1）抗体可用于内源性钙调蛋白的共免疫沉淀和免疫沉淀。
谷氨酸受体NMDAR1（NR1）抗体可在蛋白质免疫印迹中用作一抗。它还可以在免疫印迹中用于鉴定大鼠脑突触体部分的NR1。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
N-基-D-天冬氨酸受体（NMDAR1）主要在哺乳动物大脑中表达。表达基因位于人染色体9q34.3上。
NMDAR1是N-甲基 D-天冬氨酸 (NMDA) 受体的亚基，而后者是高钙渗透性谷氨酸门控离子通道的亚型。NMDA受体对镁具有独特的电压依赖性敏感性，并被甘氨酸修饰。它在神经元发育、急性和慢性神经退行性疾病的发病、突触可塑性以及记忆获得和学习中具有关键作用。抗谷氨酸受体 NMDAR1 (NR1) 抗体可用于研究 NMDAR1 在不同细胞类型和组织中的表达和功能，并基于生理功能或病理状况比较表达模式。兔抗谷氨酸受体 NMDAR1 (NR1) 抗体与源自大鼠脑的 NMDAR1 (116kD) 发生特异性反应。
Immunogen
对应于大鼠NMDAR1的C末端区域（氨基酸918-938）的合成肽。该序列与小鼠NR1、人NR1（短和长形式）和大鼠NR1同种型NR1b、NR1c和NR1f中的相应序列是相同的。
Other Notes
Physical form
溶于含有1% BSA和15 mM叠氮化钠作（pH 7.4）的 .01 M磷酸盐缓冲液。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Diego Peretti et al.
Nature, 518(7538), 236-239 (2015-01-22)
In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity. Reduction in synapse number is a consistent early feature of neurodegenerative diseases, suggesting deficient compensatory mechanisms. Although much is known
Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia
Sakurai K, et al.
Neuroscience Letters, 296(2-3), 168-170 (2000)
Integrated protein array screening and high throughput validation of 70 novel neural calmodulin binding proteins
O'Connell DJ, et al
Molecular and Cellular Proteomics (2010)
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity
Hammer C, et al.
Molecular Psychiatry, 19(10), 1143-1143 (2014)
Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity
Planaguma J, et al.
Annals of Neurology, 80(3), 388-400 (2016)
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