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形式
lyophilized powder
质量水平
颜色
white
溶解性
1% acetic acid: 1 mg/mL
water: 1 mg/mL
UniProt登记号
储存温度
−20°C
基因信息
rat ... Ghrl(59301)
Amino Acid Sequence
Gly-Ser-Ser(O-n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
一般描述
Ghrelin is a gut-brain orexigenic peptide that functions in hunger signaling. This peptide is prominently synthesized by stomach and transported to brain. However, a specific subset of hypothalamic neurons also produces this peptide. It is expressed in gastrointestinal tract, hypothalamic arcuate nucleus, pituitary, kidney, liver, heart, lung and adipose tissue This peptide is composed of 28 amino acids, and its Ser3 residue is N-octanoylated.
应用
Ghrelin rat has been used for intraperitoneal injections, and microinjections in rats to study its effects on celiac disease, and passive avoidance learning (PAV) and spatial learning, respectively. It has also been used for intracerebroventricular injection in rats to study its influence on penicillin-induced epileptiform activity in rat.
生化/生理作用
Ghrelin acts as a ligand for G-protein coupled receptor, GHS-R1A (growth hormone secretagogue receptor), and controls energy utilization and feeding. This peptide is involved in enhancing the value of rewarding foods, drugs and alcohol. In rats with diabetes, the expression of ghrelin increased as a result of cachexia. In rats with ovariectomy, the expression of this peptide decreased in the endometrium. This peptide controls cognitive functions and has neuroprotective roles in neurodegenerative disorders. In cultured cortical neuronal networks, ghrelin increases the rate of synapse formation and activity development.
Endogenous ligand to the orphan growth-hormone secretagogue receptor that stimulates the release of growth hormone from the pituitary.
外形
Lyophilized from 0.1% aqueous TFA
其他说明
Lyophilized from 0.1% TFA in H2O
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Krisztián Tóth et al.
Behavioural brain research, 202(2), 308-311 (2009-05-26)
The brain-gut peptide acylated-ghrelin (A-Ghr) is a potent growth hormone (GH) secretagogue substance. A-Ghr is also known to influence on memory and learning processes. Its effect is mediated partly via GH secretagogue receptor (GHS-R) type 1a. The amygdaloid body (AMY)
Mehmet F Sönmez et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 24(3), 401-407 (2015-10-16)
Ghrelin is a hormone which has effects on the secretion of growth hormone, the gastrointestinal system, the cardiovascular system, cell proliferation and the reproductive system. This study focused on relative ghrelin and GHS-R1a gene expression in the stomach of long-term diabetic
Miklós Sárvári et al.
PloS one, 9(5), e97651-e97651 (2014-05-17)
The orexigenic gut-brain peptide, ghrelin and its G-protein coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1A) are pivotal regulators of hypothalamic feeding centers and reward processing neuronal circuits of the brain. These systems operate in a cooperative manner and
Stewart Christie et al.
Peptides, 131, 170371-170371 (2020-07-14)
Ghrelin and anandamide (AEA) can regulate the sensitivity of gastric vagal afferents to stretch, an effect mediated via the transient receptor potential vanilloid 1 (TPRV1) channel. High fat diet (HFD)-induced obesity alters the modulatory effects of ghrelin and AEA on
Krisztián Tóth et al.
Brain research bulletin, 81(1), 33-37 (2009-10-16)
According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male
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