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Merck
CN
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文件

G8397

Sigma-Aldrich

单唾液酸神经节苷酯GM2 来源于牛大脑

≥95% (TLC)

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别名:
神经节苷酯GM2，单唾液酸
CAS号:
19600-01-2
MDL编号:
MFCD00131137
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

200

检测方案

≥95% (TLC)

储存温度

−20°C

InChI

1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1

InChI key

USMMPBVNWHAJBE-YMEOXFOQSA-N

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相关类别

Amino Acid Sequence

Cer-Glc-Gal(NeuAc)-GalNAc

一般描述

神经节苷脂GM2，一种属于鞘糖脂的单唾液酸神经节苷脂，主要分布于细胞质膜外叶。神经节苷脂是两亲性分子，含有不同糖基修饰的负电荷头基。不同种类的神经节苷脂的糖基各不相同。GM2主要在神经组织中表达。
神经节苷脂是神经元细胞膜和内质网的主要成分。 含有通过β糖苷键与神经酰胺连接的唾液酸多糖链。 有关神经节苷脂的分类，请参见Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980。

应用

单唾液酸神经节苷脂GM2（来源于牛大脑）可用于：
  • 在狗背根神经节(DRG)中研究添加GM2和去除所有细胞神经节苷脂对于神经突生长和神经元存活的影响
  • 作为高效薄层色谱法(HPTLC)参考标准品，并作为酶联免疫吸附试验(ELISA)抗原，分析人前列腺癌(CaP)细胞的神经节苷脂signatures
  • 作为GM1合酶体外活性测定反应液的组分

生化/生理作用

神经节苷脂GM2(GM2)是细胞膜的重要组分，对于细胞信号传导和代谢十分重要。多项研究表明，神经节苷脂参与癌症过程、呼肠孤病毒血清型1感染及胰岛素分泌和调节。在肿瘤细胞中，GM2参与细胞粘附、迁移和增殖，发挥保护作用。GM2表达下降代表严重的恶性肿瘤。GM2是呼肠孤病毒T1L(type 1 Lang)株的受体。神经系统相关的多种疾病中均发现GM2调节异常。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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H C Yohe et al.
Glycobiology, 7(8), 1215-1227 (1998-02-10)
Sialoglycosphingolipids (gangliosides) have been increasingly implicated as regulators of membrane signaling events. Macrophage ganglioside patterns dramatically increase in complexity when murine peritoneal macrophages are stimulated in vivo with the appearance of the sialidase-sensitive monosialoganglioside GM1b (cisGM1) as a major component.
M Sorice et al.
Bioscience reports, 19(3), 197-208 (1999-10-08)
In this study we analyzed by immunofluorescence, laser confocal microscopy, immunoelectron microscopy and label fracture technique the ganglioside distribution on the plasma membrane of several different cell types: human peripheral blood lymphocytes (PBL), Molt-4 lymphoid cells, and NIH 3T3 fibroblasts
K Nohara et al.
Breast cancer research and treatment, 48(2), 149-157 (1998-05-22)
Much evidence has shown that glycosphingolipids are involved in cellular recognition, regulation of cell growth, and metastasis. In the present study, the major glycosphingolipids of two widely studied human breast cancer cell lines were examined. The MCF-7 cell line has
Mitsuo Saito et al.
Journal of neurochemistry, 121(4), 649-661 (2012-03-01)
GM2 ganglioside in the brain increased during ethanol-induced acute apoptotic neurodegeneration in 7-day-old mice. A small but a significant increase observed 2 h after ethanol exposure was followed by a marked increase around 24 h. Subcellular fractionation of the brain
Angie Rupp et al.
Journal of the peripheral nervous system : JPNS, 18(1), 75-88 (2013-03-26)
Acute canine polyradiculoneuritis (ACP) is considered to be the canine equivalent of the human peripheral nerve disorder Guillain-Barré syndrome (GBS); an aetiological relationship, however, remains to be demonstrated. In GBS, anti-glycolipid antibodies (Abs) are considered as important disease mediators. To
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