产品名称
Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse
technique(s)
immunohistochemistry: 1 μg/mL using mouse embryo brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GNRH1(2796)
mouse ... Gnrh1(14714)
rat ... Gnrh1(25194)
Application
Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit is suitable for immunoprecipitation of GnRH purified from adult amphioxus tissues. It is suitable for immunohistochemistry at a working concentration of 1μg/mL using mouse embryo brain.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Biochem/physiol Actions
Gonadotropin releasing hormone (GnRH) is crucial for the regulation of reproduction in vertebrates. It is a decapeptide and is expressed by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. Neural, hormonal and environmental stimuli affect the generation of GnRH pulses, which in turn affect the secretion of follicle stimulating hormone(FSH) and luteinizing hormone (LH) from the pituitary. It may be involved in mediating cancers of the reproductive system.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
synthetic peptide pyroEHWSYGLRP(G-NH2) corresponding to human GnRH. The sequence is completely conserved in rat and tree shrew and 78% conserved in zebrafish.
Physical form
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Errol R Norwitz et al.
Endocrinology, 143(3), 985-997 (2002-02-28)
The response of pituitary gonadotropes to GnRH correlates directly with the concentration of GnRH receptors (GnRHRs) on the cell surface, which is mediated in part at the level of GnRHR gene expression. We have previously localized GnRH responsiveness in the
Shifeng Xue et al.
Nature communications, 13(1), 3583-3583 (2022-06-24)
The body plan of animals is laid out by an evolutionary-conserved HOX code which is colinearly transcribed after zygotic genome activation (ZGA). Here we report that SMCHD1, a chromatin-modifying enzyme needed for X-inactivation in mammals, is maternally required for timely
Natalie D Shaw et al.
Nature genetics, 49(2), 238-248 (2017-01-10)
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a
R M Moretti et al.
Endocrine-related cancer, 10(2), 161-167 (2003-06-07)
Luteinizing hormone-releasing hormone (LHRH) is the key hormone in the control of reproductive functions. In recent years, it has become evident that LHRH might act as a growth modulatory factor in tumors of the reproductive system. We have shown that
Erica E Davis et al.
Human molecular genetics, 29(14), 2435-2450 (2020-07-06)
Dysfunction of the gonadotropin-releasing hormone (GnRH) axis causes a range of reproductive phenotypes resulting from defects in the specification, migration and/or function of GnRH neurons. To identify additional molecular components of this system, we initiated a systematic genetic interrogation of
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