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Merck
CN

G8293

Galanin (2-11) porcine, rat

≥97% (HPLC), lyophilized powder

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关于此项目

经验公式(希尔记法):
C54H81N13O14
分子量:
1136.30
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥97% (HPLC)
Form:
lyophilized powder
Quality level:
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InChI key

SUJPPMXJCZETOA-ZKEPBWIVSA-N

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)[C@@H](C)O)C(N)=O

InChI

1S/C54H81N13O14/c1-26(2)17-37(46(57)73)62-49(76)38(18-27(3)4)63-51(78)40(20-31-13-15-33(70)16-14-31)61-44(72)24-59-47(74)29(7)60-53(80)42(25-68)66-52(79)41(22-43(56)71)64-50(77)39(19-28(5)6)65-54(81)45(30(8)69)67-48(75)35(55)21-32-23-58-36-12-10-9-11-34(32)36/h9-16,23,26-30,35,37-42,45,58,68-70H,17-22,24-25,55H2,1-8H3,(H2,56,71)(H2,57,73)(H,59,74)(H,60,80)(H,61,72)(H,62,76)(H,63,78)(H,64,77)(H,65,81)(H,66,79)(H,67,75)/t29-,30+,35-,37-,38-,39-,40-,41-,42-,45-/m0/s1

biological source

synthetic

assay

≥97% (HPLC)

form

lyophilized powder

composition

Peptide content, ≥65%

UniProt accession no.

storage temp.

−20°C

Quality Level

Gene Information

rat ... Gal(29141)

General description

Galanin (2-11) is a galanin receptor type 2 agonist.

Biochem/physiol Actions

Studies in mice show that injection of galanin (2-11) has anticonvulsant activity in seizure affected animals with an intact DR (dorsal root)–hippocampal serotonergic profile, and has no effect in animals with absent 5-HT (hydroxytryptamine) profile.

Other Notes

Lyophilized from 0.1% TFA in H2O

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Andrey M Mazarati et al.
Journal of neurochemistry, 95(5), 1495-1503 (2005-10-13)
The neuropeptide galanin suppresses seizure activity in the hippocampus by inhibiting glutamatergic neurotransmission. Galanin may also modulate limbic seizures through interaction with other neurotransmitters in neuronal populations that project to the hippocampus. We examined the role of galanin receptors types
Xiaoying Lu et al.
Neuropeptides, 39(3), 165-167 (2005-06-10)
The neuropeptide galanin regulates a variety of physiological and pathophysiological processes through three G protein coupled receptors, GalR1, GalR2, and GalR3. The studies on galanin receptor subtype specific effects have been hampered by the lack of high affinity subtype selective

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