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安全信息

G8147

Sigma-Aldrich

胰高血糖素样肽 Ⅰ 酰胺片段 7-36 人

≥97% (HPLC), powder

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别名:
前胰高血糖素原 78-107 酰胺
经验公式（希尔记法）:
C149H226N40O45
CAS号:
107444-51-9
分子量:
3297.63
MDL编号:
MFCD00133373
UNSPSC代码:
51111800
PubChem化学物质编号:
329799974
NACRES:
NA.32

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

UniProt登记号

P01275

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc5c[nH]c6ccccc56)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1

InChI key

DTHNMHAUYICORS-KTKZVXAJSA-N

基因信息

human ... GCG(2641)

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Amino Acid Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

一般描述

胰高血糖素样肽 1 (GLP-1) 肽来自胰高血糖素原，无代谢活性。不过它可被加工成两种较小的酰胺形式，即 GLP-1 (7-37) 酰胺和 GLP-1 (7-36) 酰胺。它是一种天然的胃肠肽。

应用

人胰高血糖素样肽 I 酰胺片段 7-36 在 DMEM (Dulbeccos) 培养基中用于培养 3T3-L1 脂肪细胞，以研究脂肪组织 GLP-1 受体与肥胖和胰岛素抵抗之间的关系。
人胰高血糖素样肽(GLP)I 7-36酰胺片段作为GLP-1受体激动剂的应用实例：
  • 在裂解物环磷酸腺苷(cAMP)荧光能量共振转移法中检测其对腺苷酸环化酶活性的影响
  • 预处理人脐静脉内皮细胞(HUVEC)，以便检测其对内皮细胞(EC)高渗透性和肌动蛋白细胞骨架变化的影响
  • 检测其对大鼠肠系膜动脉中基于血管内皮生长因子-A(VEGFA)的血管舒张的影响

生化/生理作用

GLP-1（胰高血糖素样肽 1）(7-36) 酰胺是一种强效促胰岛素分泌肽，可启动餐后或口服葡萄糖后葡萄糖诱导的胰岛素释放。它具有抗糖尿病作用，因此可能用于治疗非胰岛素依赖型糖尿病。

其他说明

冻干自H2O 0.1% TFA

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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A Vella et al.
Diabetologia, 45(10), 1410-1415 (2002-10-16)
The aim of this study was to determine whether rapid conversion to inactive and potentially antagonistic peptides could alter the response to GLP-1. We evaluated the ability of exendin-4, a GLP-1 analogue resistant to degradation by dipeptidyl peptidase IV, to
W Creutzfeldt
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 109 Suppl 2, S288-S303 (2001-07-20)
The search for intestinal factors regulating the endocrine secretion of the pancreas started soon after the discovery of secretin, i.e. nearly 100 years ago. Insulinotropic factors of the gut released by nutrients and stimulating insulin secretion in physiological concentrations in
B D Green et al.
Metabolism: clinical and experimental, 53(2), 252-259 (2004-02-10)
The incretin hormone glucagon-like peptide-1(7-36)amide (GLP-1) has been deemed of considerable importance in the regulation of blood glucose. Its effects, mediated through the regulation of insulin, glucagon, and somatostatin, are glucose-dependent and contribute to the tight control of glucose levels.
Sang-Heon Lee et al.
Bioconjugate chemistry, 16(2), 377-382 (2005-03-17)
Glucagon-like peptide-1-(7-36) (GLP-1) is a hormone derived from the proglucagon molecule, which is considered a highly desirable antidiabetic agent mainly due to its unique glucose-dependent stimulation of insulin secretion profiles. However, the development of a GLP-1-based pharmaceutical agent has a
Sibel Ozyazgan et al.
Pharmacology, 74(3), 119-126 (2005-03-05)
We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a
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