推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
检测方案
≥95% (SDS-PAGE)
形式
lyophilized powder
UniProt登记号
应用
cell analysis
储存温度
−20°C
基因信息
human ... LGALS1(3956)
一般描述
Galectin-1 is a member of the family of animal lectins, which selectively binds β-galactoside residues.
应用
A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. They have variable affinity for more complex oligosaccharides. Other activities of galectin-1 include cell differentiation and inhibition of CD45 protein phosphatase activity.
生化/生理作用
Galectin-1 has been implicated in metastasis and aggregation of cancer cells based on its association with the glycoprotein 90K. Galectin-1 may play a significant role in cancer through apoptosis, cell adhesion, migration, cell cycle regulation and tumor evasion of immune responses.
Galectin-1 has been implicated in metastasis and aggregation of cancer cells based on its association with the glycoprotein 90K. Galectin-1 may play a significant role in cancer through apoptosis, cell adhesion and migration, regulation of the cell cycle and tumor evasion of immune responses.
外形
Lyophilized from a 5 mg/mL solution in phosphate buffered saline containing 8 mM DTT and 150 mM lactose.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Zanka Bojić-Trbojević et al.
Histochemistry and cell biology, 142(5), 541-553 (2014-05-24)
Mucins are multifunctional highly glycosylated proteins expressed by the female reproductive tract. Differential expression of MUC1 and MUC15 has been shown in trophoblast. This study was undertaken to establish the distribution of mucin(s) in cytotrophoblast cell cultures using anti-bovine submaxillary
F Archambeaud-Mouveroux et al.
Gastroenterologie clinique et biologique, 11(1), 93-95 (1987-01-01)
A case of secondary syphilitic hepatitis is reported. A 49-year old woman was admitted for weight-loss, fever, hepatomegaly and splenomegaly. Diagnosis of syphilitic hepatitis was based on cholestasis associated with positive serologic tests for syphilis without other immunological disturbances. Biopsy
Antonino Grassadonia et al.
Glycoconjugate journal, 19(7-9), 551-556 (2004-02-06)
Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. Mac-2 BP, also known as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin-1, galectin-3
Debora B Petropolis et al.
PLoS pathogens, 10(9), e1004381-e1004381 (2014-09-12)
Investigations of human parasitic diseases depend on the availability of appropriate in vivo animal models and ex vivo experimental systems, and are particularly difficult for pathogens whose exclusive natural hosts are humans, such as Entamoeba histolytica, the protozoan parasite responsible
Sandra Thiemann et al.
The Journal of biological chemistry, 290(37), 22662-22677 (2015-07-29)
During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic
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