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安全信息

G6423

Sigma-Aldrich

吉西他滨

≥98% (HPLC), powder, antitumor agent

别名:

2';-脱氧-2',2'-二氟胞苷; dFDC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd

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About This Item

经验公式（希尔记法）:
C9H11F2N3O4 · HCl
CAS号:
122111-03-9
分子量:
299.66
MDL编号:
MFCD01735988
UNSPSC代码:
12352200
PubChem化学物质编号:
329799951
NACRES:
NA.77
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产品名称

吉西他滨, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated
protect from light

溶解性

H2O: ≥10 mg/mL

创始人

Eli Lilly

储存温度

room temp

SMILES字符串

Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F

InChI

1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1

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此商品
198269SML1229A2846
Gemcitabine hydrochloride ≥98% (HPLC)

G6423

Gemcitabine hydrochloride

Erythrosin B certified by the BSC, Dye content ≥85 %

198269

Erythrosin B

2′,3′-cGAMP sodium salt ≥98% (HPLC)

SML1229

2′,3′-cGAMP sodium salt

A-134974 dihydrochloride hydrate ≥98% (HPLC), solid

A2846

A-134974 dihydrochloride hydrate

form

powder

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

storage temp.

-

solubility

H2O: ≥10 mg/mL

solubility

H2O: 1 mg/mL, clear

solubility

-

solubility

H2O: soluble

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

storage condition

desiccated

一般描述

Gemcitabineis a pyrimidine nucleoside analog of deoxycytidine. It exhibits anticancereffects against various cancers.[1]

应用

Gemcitabinehydrochloride has been used as a chemotherapeutic agent to study its effects onthe human pancreatic adenocarcinoma cell line[2]It has been used as a chemotherapeutic to study its resistance inpancreatic stellate cells (PSCs)[3]It has also been used to study its effects on patient-derivedxenograft (PDX) organoids.[4]

生化/生理作用

吉西他滨是诊所和研究实验室中广泛使用的抗肿瘤药物。它是一种抗肿瘤药和抗代谢药。

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000302269
    0000302269
    0000174095
    0000298874
    0000408869

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    访问文档库

    M Barton-Burke
    Cancer nursing, 22(2), 176-183 (1999-04-27)
    There have been exciting new developments in anticancer therapy over the past few years. One such therapy uses gemcitabine (GemzarR), an antimetabolite approved in 1996 by the Food and Drug Administration (FDA) for first-line treatment of locally advanced (nonresectable stage
    Abdullah Shopit et al.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153711-153711 (2021-08-28)
    Gemcitabine (GCB) is a first-line chemotherapeutic drug for pancreatic cancer (PCa). However, the resistance begins developing within weeks of chemotherapy. SPINK1 overexpression enhances resistance to chemotherapy. In a recent study, our laboratory established that the oleanolic acid (OA) derivative, K73-03
    Yuan Chi et al.
    Frontiers in oncology, 11, 671082-671082 (2021-12-07)
    Pancreatic cancer is associated with poor prognosis and dismal survival rates. This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by pancreatic stellate cells (PSCs) in Gemcitabine (Gem) resistance of pancreatic cancer under hypoxia, which involves the methylation
    Isabel Romero-Calvo et al.
    Molecular cancer research : MCR, 17(1), 70-83 (2018-09-02)
    Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great promise for understanding the biological underpinnings of disease and advancing therapeutic precision medicine. Despite the increased use of organoids, the fidelity of molecular features, genetic heterogeneity, and drug response to the
    Jun Young Park et al.
    Molecular therapy. Nucleic acids, 12, 543-553 (2018-09-10)
    Gemcitabine has been considered a first-line chemotherapy agent for the treatment of pancreatic cancer. However, the initial response rate of gemcitabine is low and chemoresistance occurs frequently. Aptamers can be effectively internalized into cancer cells via binding to target molecules
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