推荐产品
产品名称
抗- 胶质纤维酸性蛋白抗体,小鼠单克隆, clone G-A-5, purified from hybridoma cell culture
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
G-A-5, monoclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
rat, human, pig
浓度
~1.0 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GFAP(2670)
mouse ... Gfap(14580)
pig ... GFAP(396562)
rat ... Gfap(24387)
一般描述
神经胶质原纤维酸性蛋白(GFAP)是存在于星形胶质细胞中的中间丝,以10种不同的亚型进行表达。它由N端头部、中心杆和C端尾部结构域组成。GFAP位于人类染色体17q21.33。
免疫原
纯化的猪脊髓 GFAP。
应用
神经胶质纤维酸性蛋白单克隆抗体适用于蛋白印迹和间接免疫荧光(2.5-5 μg/mL,使用酒精固定的大鼠脑/小脑切片)。该抗体还可用于免疫印迹(约50 kDa)、免疫组化(多聚甲醛固定的兔脑冷冻切片)和免疫细胞化学。
神经胶质纤维酸性蛋白抗体(小鼠单克隆抗体)可用于免疫细胞化学和免疫荧光。
生化/生理作用
神经胶质纤维酸性蛋白或GFAP组装与神经胶质结构的有丝分裂重塑有关。GFAP基因突变与亚历山大病有关。
神经胶质纤维酸性蛋白(GFAP)基因位点的微缺失与儿童智力残疾和面部畸形有关。GFAP水平升高与急性脑出血有关。
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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抗体
产品编号
说明
价格
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants.
Govindaiah Vinukonda et al.
Journal of neuroscience research, 90(11), 2173-2182 (2012-07-19)
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Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways
Tse KH, et al.
Neuroscience, 267, 241 -2251 (2014)
Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system
Hol EM and Pekny M
Current Opinion in Cell Biology, 32, 121-130 (2015)
TWO CASES WITH DIFFERENT EPILEPSY TYPE AND DYSMORPHIC FEATURES ASSOCIATED WITH 17q21. 31 MICRODELETION SYNDROME
Uctepe E, et al.
Genetic Counseling (Geneva, Switzerland), 27(3), 357-365 (2016)
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