G6171
Anti-Glial Fibrillary Acidic Protein Antibody
mouse monoclonal, G-A-5
别名:
抗 GFAP
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关于此项目
Conjugate:
unconjugated
Clone:
G-A-5, monoclonal
Application:
immunocytochemistry
immunohistochemistry
indirect immunofluorescence
western blot
immunohistochemistry
indirect immunofluorescence
western blot
Species reactivity:
rat, human, pig
Citations:
103
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.
western blot: suitable
immunohistochemistry: suitable
indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.
western blot: suitable
Uniprot accession no.:
产品名称
抗- 胶质纤维酸性蛋白抗体，小鼠单克隆, clone G-A-5, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
purified immunoglobulin
antibody product type
primary antibodies
clone
G-A-5, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
rat, human, pig
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.
western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GFAP(2670)
mouse ... Gfap(14580)
pig ... GFAP(396562)
rat ... Gfap(24387)
Application
神经胶质纤维酸性蛋白单克隆抗体适用于蛋白印迹和间接免疫荧光（2.5-5 μg/mL，使用酒精固定的大鼠脑/小脑切片）。该抗体还可用于免疫印迹（约50 kDa）、免疫组化（多聚甲醛固定的兔脑冷冻切片）和免疫细胞化学。
神经胶质纤维酸性蛋白抗体（小鼠单克隆抗体）可用于免疫细胞化学和免疫荧光。
Biochem/physiol Actions
神经胶质纤维酸性蛋白或GFAP组装与神经胶质结构的有丝分裂重塑有关。GFAP基因突变与亚历山大病有关。
神经胶质纤维酸性蛋白（GFAP）基因位点的微缺失与儿童智力残疾和面部畸形有关。GFAP水平升高与急性脑出血有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
神经胶质原纤维酸性蛋白（GFAP）是存在于星形胶质细胞中的中间丝，以10种不同的亚型进行表达。它由N端头部、中心杆和C端尾部结构域组成。GFAP位于人类染色体17q21.33。
Immunogen
纯化的猪脊髓 GFAP。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation
Ito K, et al.
Scientific Reports, 6, 23903-23903 (2016)
Plasma glial fibrillary acidic protein in the differential diagnosis of intracerebral hemorrhage
Katsanos AH, et al.
Stroke, 48(9), 2586 -22588 (2017)
M Inagaki et al.
Brain pathology (Zurich, Switzerland), 4(3), 239-243 (1994-07-01)
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein of astroglia, and belongs to the type III subclass of IF proteins. IF proteins are composed of an amino-terminal HEAD domain, a central ROD domain and a carboxyterminal TAIL
Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system
Hol EM and Pekny M
Current Opinion in Cell Biology, 32, 121-130 (2015)
TWO CASES WITH DIFFERENT EPILEPSY TYPE AND DYSMORPHIC FEATURES ASSOCIATED WITH 17q21. 31 MICRODELETION SYNDROME
Uctepe E, et al.
Genetic Counseling (Geneva, Switzerland), 27(3), 357-365 (2016)
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