跳转至内容
Merck
CN
所有图片(1)

文件

安全信息

G5773

Sigma-Aldrich

Galanin porcine

≥97% (HPLC), powder

登录查看公司和协议定价
所有图片(1)
经验公式（希尔记法）:
C146H213N43O40
CAS号:
88813-36-9
分子量:
3210.52
MDL编号:
MFCD00133353
UNSPSC代码:
12352200
PubChem化学物质编号:
24895230

检测方案

≥97% (HPLC)

形式

powder

UniProt登记号

P07480

储存温度

−20°C

SMILES字符串

CCC(C)C(NC(=O)C(C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C2CCCN2C(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc3ccc(O)cc3)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)CN)C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(Cc6cnc[nH]6)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(Cc7ccccc7)C(=O)NC(Cc8cnc[nH]8)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(Cc9ccc(O)cc9)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(N)=O

InChI

1S/C146H213N43O40/c1-15-75(10)119(187-123(207)78(13)167-129(213)101(51-84-60-154-68-162-84)182-143(227)110-31-24-42-189(110)116(200)65-161-124(208)93(43-71(2)3)173-130(214)95(45-73(6)7)174-132(216)98(49-82-34-38-88(194)39-35-82)170-114(198)63-159-122(206)77(12)166-141(225)108(66-190)186-137(221)105(55-112(150)196)179-131(215)96(46-74(8)9)183-145(229)120(79(14)192)188-140(224)100(168-113(197)58-148)50-83-59-158-90-28-20-19-27-89(83)90)144(228)184-107(57-118(203)204)139(223)180-104(54-111(149)195)136(220)178-102(52-85-61-155-69-163-85)134(218)172-92(30-23-41-157-146(152)153)127(211)185-109(67-191)142(226)176-99(47-80-25-17-16-18-26-80)133(217)177-103(53-86-62-156-70-164-86)135(219)181-106(56-117(201)202)138(222)171-91(29-21-22-40-147)126(210)175-97(48-81-32-36-87(193)37-33-81)125(209)160-64-115(199)169-94(44-72(4)5)128(212)165-76(11)121(151)205/h16-20,25-28,32-39,59-62,68-79,91-110,119-120,158,190-194H,15,21-24,29-31,40-58,63-67,147-148H2,1-14H3,(H2,149,195)(H2,150,196)(H2,151,205)(H,154,162)(H,155,163)(H,156,164)(H,159,206)(H,160,209)(H,161,208)(H,165,212)(H,166,225)(H,167,213)(H,168,197)(H,169,199)(H,170,198)(H,171,222)(H,172,218)(H,173,214)(H,174,216)(H,175,210)(H,176,226)(H,177,217)(H,178,220)(H,179,215)(H,180,223)(H,181,219)(H,182,227)(H,183,229)(H,184,228)(H,185,211)(H,186,221)(H,187,207)(H,188,224)(H,201,202)(H,203,204)(H4,152,153,157)

InChI key

SLZIZIJTGAYEKK-UHFFFAOYSA-N

基因信息

pig ... GAL(397465)

正在寻找类似产品? 访问 产品对比指南

Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2

一般描述

Galanin is a biologically active peptide found in porcine intestine, and is called so because of the presence of glycine and alanine at N- and C-terminals, respectively. Its C-terminal contains alanine amide. It is composed of 29 amino acids namely, Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. This peptide shows wide expression in peripheral and central nervous system. In brain, its predominant expression is in hypothalamus, especially in the nerve terminals of the median eminence.

应用

Galanin porcine has been used for the pre-absorption of anti-Gal serum, as control, to determine the specificity of immunoreaction during immunocytochemistry on brains obtained from river lampreys (Lampetra fluviatilis L.).

生化/生理作用

Studies show that galanin is capable of producing sustained but mild hyperglycemia in dogs. It also induces contraction in smooth muscle preparations obtained from fundus strip, ileum, colon and urinary bladder from rats. It shows structural similarities at the C-terminal to other neuropeptides, and thus, might also function as a neuropeptide. This peptide is a candidate hypothalamic-hypophysiotropic hormone, and is thought to affect the release of various pituitary hormones, such as growth hormone (GH), prolactin (PRL), and luteinizing hormone (LH).
Co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca2+ channels; linked to behavioral and cognitive deficits in Alzheimer′s disease.

其他说明

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

P Vento et al.
Digestive diseases and sciences, 43(5), 1102-1110 (1998-05-20)
The aim of this study was to evaluate possible changes in the neuropeptide innervation pattern of the remaining porcine ileum following 75% proximal resection of the small intestine. Three-month-old piglets were operated on and two months postoperatively full-thickness specimens of
Liuyin Zhang et al.
Molecular pharmaceutics, 10(2), 574-585 (2012-12-25)
Delivery of neuropeptides into the central and/or peripheral nervous systems supports development of novel neurotherapeutics for the treatment of pain, epilepsy and other neurological diseases. Our previous work showed that the combination of lipidization and cationization applied to anticonvulsant neuropeptides
Masoumeh Motamedi Joibari et al.
Obesity (Silver Spring, Md.), 21(1), 130-134 (2013-03-19)
Ghrelin, orexin, and galanin are orexigenic factors in rodents and humans which participate in adaptive response to weight loss. On the other hand, weight loss and fasting is accompanied by increased levels of epinephrine (Ep) and cortisol (Cor). In this
K Tatemoto et al.
FEBS letters, 164(1), 124-128 (1983-11-28)
The isolation of a novel biologically active peptide, designated galanin, is described. The peptide was discovered by the detection of its C-terminal amide structure in porcine intestinal extract using a chemical method. It was found that galanin consists of 29
Brad R Green et al.
Bioorganic & medicinal chemistry, 21(1), 303-310 (2012-11-28)
Hydrocarbon stapling is an effective strategy to stabilize the helical conformation of bioactive peptides. Here we describe application of stapling to anticonvulsant neuropeptides, galanin (GAL) and neuropeptide Y (NPY), that are implicated in modulating seizures in the brain. Dicarba bridges
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门