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G5668

Sigma-Aldrich

GW1929 水合物

>98% (HPLC), solid

别名:

水合物

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1 EA
CN¥11,407.80

CN¥11,407.80

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1 EA
CN¥11,407.80

About This Item

经验公式（希尔记法）:
C30H29N3O4 · xH2O
CAS号:
1049740-86-4
分子量:
495.57 (anhydrous basis)
MDL编号:
MFCD11045925
UNSPSC代码:
12352200
PubChem化学物质编号:
24278789
NACRES:
NA.77

CN¥11,407.80

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质量水平

100

方案

>98% (HPLC)

表单

solid

溶解性

DMSO: 20 mg/mL

创始人

GlaxoSmithKline

SMILES字符串

[H]O[H].CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(O)=O)cc1)c4ccccn4

InChI

1S/C30H29N3O4.H2O/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-21H2,1H3,(H,35,36);1H2/t27-;/m0./s1

InChI key

XSITZVFUXCLFMK-YCBFMBTMSA-N

基因信息

human ... PPARG(5468)

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1 of 4

此商品
67034U67033U66825U
BIOshell A400 Protein C4, 3.4 μm HPLC Column 3.4 μm particle size, L × I.D. 15 cm × 300 μm

67039U

BIOshell A400 Protein C4, 3.4 μm HPLC Column

BIOshell A400 Protein C4, 3.4 μm HPLC Column 3.4 μm particle size, L × I.D. 15 cm × 100 μm

67034U

BIOshell A400 Protein C4, 3.4 μm HPLC Column

Supelco

67033U

BIOshell A400 Protein C4, 3.4 μm HPLC Column

BIOshell A400 Protein C4, 3.4 μm HPLC Column 3.4 μm particle size, L × I.D. 10 cm × 2.1 mm

66825U

BIOshell A400 Protein C4, 3.4 μm HPLC Column

matrix

spherical silica particle platform, superficially porous particle

matrix

spherical silica particle platform, superficially porous particle

matrix

spherical silica particle platform, superficially porous particle

matrix

spherical silica particle platform, superficially porous particle

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

particle size

3.4 μm

particle size

3.4 μm

particle size

3.4 μm

particle size

3.4 μm

matrix active group

C4 (butyl) phase

matrix active group

C4 (butyl) phase

matrix active group

C4 (butyl) phase

matrix active group

C4 (butyl) phase

pore size

400 Å

pore size

400 Å

pore size

400 Å

pore size

400 Å

technique(s)

HPLC: suitable, UHPLC-MS: suitable, LC/MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

应用

GW1929已被用作过氧化物酶体增殖物激活受体γ (PPARγ) 配体：
  • 研究对参与脂肪生成的植物同源结构域指蛋白16 (Phf16)和含patatin样磷脂酶域3 (Pnpla3)表达的影响[1]
  • 研究对人肝癌细胞补体成分3 (C3)基因表达的影响[2]
  • 激活人乳腺癌细胞中的PPARγ[3]

生化/生理作用

GW1929 是 PPAR-γ 的高亲和力激动剂。
GW1929是非噻唑烷二酮，参与细胞生长抑制和调控基因表达。[4]通过DNA片段化对全脑缺血-再灌注损伤具有神经保护作用，可减轻炎症反应。[5]GW1929参与抑制α7 N-乙酰胆碱受体表达和启动子活性。它还影响早期生长反应-1 (Egr-1)蛋白的表达。[4]

特点和优势

该化合物在受体分类和信号转导手册的 核受体（PPAR） 页面上有详细描述。如需浏览其他手册页面，请点击此处。
该化合物由 葛兰素史克 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

法律信息

根据与葛兰素史克公司达成的协议，销售仅限于研究目的

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000380855
0000242261
0000380855
0000242261
129K4708V

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Miaozhen Pan et al.
Experimental eye research, 202, 108332-108332 (2020-11-06)
Form deprivation myopia (FDM) is characterized by loss of choroidal thickness (ChT), reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some tissues, changes in levels of peroxisome proliferator-activated receptor γ (PPARγ) expression modulate hypoxia-induced pathological responses. We determined
Swei Sunny Hahn et al.
Cellular signalling, 26(4), 730-739 (2014-01-15)
Studies demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) ligands reduce nicotine-induced non small cell lung carcinoma (NSCLC) cell growth through inhibition of nicotinic acetylcholine receptor (nAChR) mediated signaling pathways. However, the mechanisms by which PPARγ ligands inhibited nAChR expression remain
Seo-Hyuk Chang et al.
Journal of cellular biochemistry, 120(3), 3599-3610 (2018-10-03)
Adipocyte differentiation is controlled by multiple signaling pathways. To identify new adipogenic factors, C3H10T1/2 adipocytes were treated with previously known antiadipogenic phytochemicals (resveratrol, butein, sulfuretin, and fisetin) for 24 hours. Commonly regulated genes were then identified by transcriptional profiling analysis. Three
Ravinder K Kaundal et al.
Behavioural brain research, 216(2), 606-612 (2010-09-14)
Transient global cerebral ischemia results in acute neurodegeneration in selective brain areas. Global cerebral ischemic-reperfusion (IR) injury induced selective hippocampal damage results into various neurobehavioral deficits including spatial memory and learning deficiencies. In this study, we have investigated the protective
Vladimir S Shavva et al.
European journal of cell biology, 97(3), 204-215 (2018-03-20)
C3 is an acute phase protein, and thus its plasma concentration increases quickly and drastically during the onset of inflammation. Insulin plays a complex role in inflammation. Elevated level of plasma C3 was shown to correlate with heightened fasting insulin
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